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Fig. 4 | BMC Cancer

Fig. 4

From: Hyperfunction of CD4 CD25 regulatory T cells in de novo acute myeloid leukemia

Fig. 4

AML Treg-mediated immunosuppression for immune T cells. a. Both normal Tregs (n = 3) and AML Tregs (n = 3) resulted in increased apoptosis of T cells compared with CD4+CD25- T cells cultured alone, particularly AML Tregs. b. Compared with normal Tregs (n = 3), AML Tregs (n = 3) had the same trend of progression of CD8+ T cells, however the differences remained not statistically significant (P > 0.05). c. AML Tregs inhibited the proliferation of CD4+CD25- T cells (AML patients n = 3; controls n = 3). d. AML Tregs could not inhibit the proliferation of CD8+ T cells (AML patients n = 3; controls n = 3). e. The levels of IFN-γ showed that T cells from both normal controls and AML patients cocultured with AML Tregs had significantly lower levels of IFN-γ production than those of controls. CD8+ T cells showed the same trend, but the differences were not statistically significant. (AML patients n = 7; controls n = 6). f. The inhibitory effect was not observed for TNF-α (P > 0.05). (AML patients n = 7; controls n = 6). Data were expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001

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