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Fig. 3 | BMC Cancer

Fig. 3

From: Hyperfunction of CD4 CD25 regulatory T cells in de novo acute myeloid leukemia

Fig. 3

The enhancement of migratory capacity of Tregs due to higher expression of CXCR4 in AML. a-c. PB Tregs from AML patients (n = 3) had higher migratory capacity towards (a) SDF-1α, (b) normal BM, and (c) AML BM than those in controls (n = 3). CXCR4 blockade resulted in significantly reduced migratory capacity of Tregs in controls and AML, with no significant differences. d. The same PB Tregs showed similar migratory capacities to normal BM fluid or AML BM fluid. e-f. The level of SDF-1α in BM fluid from patients (n =1 1) and controls (n = 14) was similar (P = 0.1380). BM fluid had increased level of SDF-1 compared with serum in AML patients (n = 11). Data were expressed as mean ± SEM. ns P > 0.05, **P < 0.01. g-h. The expression of CXCR4 and CXCR7 on the surface of Tregs. There was significantly higher expression of CXCR4 on PB Tregs from AML patients (n = 8) compared with controls (n = 5) (P = 0.0310), while there was no significant difference in CXCR7 expression on PB Tregs between the 2 groups (AML patients n = 7; controls n = 6). Data were expressed as Median (P25, P75)

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