Fig. 6From: Discrimination between clinical significant and insignificant prostate cancer with apparent diffusion coefficient – a systematic review and meta analysisa Forrest plots of the mean apparent diffusion coefficients of the subgroup analysis of clinical insignificant PC in accordance to endorectal coil. The pooled mean ADC value was 1.16 × 10− 3 mm2/s [95% CI 1.01–1.31] for lesions investigated with endorectal coils and 1.07 × 10− 3 mm2/s [95% CI 0.98–1.15] for tumors without. b. Forrest plots of the mean apparent diffusion coefficients of the subgroup analysis of clinical insignificant PC in accordance to histopathology specimen. For PC investigated histopathologically after radical prostatectomy the pooled mean ADC value was 1.10 × 10− 3 mm2/s [95% CI 1.01–1.19] and it was 1.12 × 10− 3 mm2/s [95% CI 0.95–1.28] for lesions, which were classified based on bioptic specimens. c. Forrest plots of the mean apparent diffusion coefficients of the subgroup analysis of clinical insignificant PC in accordance to tesla strength. The pooled mean ADC value was 1.10 × 10− 3 mm2/s [95% CI 1.01–1.20] for lesions investigated by 3 T scanners and 1.06 × 10− 3 mm2/s [95% CI 0.97–1.16 for PC investigated by 1.5 T scanners. d. Forrest plots of the mean apparent diffusion coefficients of the subgroup analysis of clinically significant PC in accordance to endorectal coil. The pooled mean ADC value was 0.89 × 10− 3 mm2/s [95% CI 0.80–0.98] for lesions investigated with endorectal coils and 0.84 × 10− 3 mm2/s [95% CI 0.81–0.88] for PC investigated without endorectal coils. e. Forrest plots of the mean apparent diffusion coefficients of the subgroup analysis of clinically significant PC in accordance to histopathological specimens. For PC investigated histopathologically after radical prostatectomy the pooled mean ADC value was 0.85 × 10− 3 mm2/s [95% CI 0.80–0.91, Tau2 = 0.02, Chi2 = 728.04, df = 25, I2 = 97%], and it was 0.87 × 10− 3 mm2/s [95% CI 0.82–0.92, Tau2 = 0.01, Chi2 = 310.2, df = 21, I2 = 93%] for lesions investigated on bioptic specimens. f. Forrest plots of the mean apparent diffusion coefficients of the subgroup analysis of clinically significant PC in accordance to tesla strength. The pooled mean ADC value was 0.87 × 10− 3 mm2/s [95% CI 0.83–0.92] for PC investigated by 3 T scanners and 0.83 × 10− 3 mm2/s [95% CI 0.76–0.89] for tumors analyzed by 1.5 T scannersBack to article page