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Table 1 Multivariate cox analysis of associations between PPFIA1 protein expression and clinicopathological parameters in luminal breast cancer

From: PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer

Luminal breast cancer cohort

 

Recurrence free survival

HR (95% CI)

P

P*

PPFIA1

1.7 (1.1–2.6)

0.004

0.01

Tumour size

1.4 (1.1–1.9)

0.031

0.038

Tumour grade

1.3 (1.1–1.6)

0.017

0.02

Nodal stage

1.4 (1.1–1.8)

0.001

0.005

 

Distant metastasis free survival

HR (95% CI)

P

P*

PPFIA1

1.4 (0.9–2.1)

0.05

0.06

Tumour size

1.7 (1.2–2.4)

0.001

0.002

Tumour grade

1.4 (1.1–1.8)

0.003

0.005

Nodal stage

1.5 (1.1–1.9)

0.0007

0.003

 

Breast cancer specific survival

HR (95% CI)

P

P*

PPFIA1

1.6 (1.1–2.6)

0.02

0.025

Tumour size

1.8 (1.3–2.7)

0.0008

0.001

Tumour grade

1.7 (1.3–2.3)

0.00004

0.0002

Nodal stage

1.5 (1.2–2.0)

0.0007

0.001

Endocrine-treated cohort

 

Recurrence free survival

HR (95% CI)

P

P*

PPFIA1

2.5 (1.3–5.0)

0.006

0.01

Tumour size

2.0 (1.2–3.5)

0.0053

0.01

Tumour grade

1.5 (1.0–2.3)

0.048

0.06

Nodal stage

1.7 (1.1–2.4)

0.0051

0.02

 

Distant metastasis free survival

HR (95% CI)

P

P*

PPFIA1

2.4 (1.2–4.7)

0.009

0.01

Tumour size

1.9 (1.1–3.2)

0.01

0.012

Tumour grade

2.0 (1.2–3.1)

0.002

0.005

Nodal stage

1.8 (1.2–2.6)

0.001

0.005

 

Breast cancer specific survival

HR (95% CI)

P

P*

PPFIA1

2.8 (1.3–5.8)

0.005

0.008

Tumour size

2.4 (1.3–4.1)

0.002

0.005

Tumour grade

2.6 (1.6–4.4)

0.0001

0.0005

Nodal stage

1.6 (1.1–2.5)

0.009

0.01

  1. P*: Adjusted p-value