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Fig. 2 | BMC Cancer

Fig. 2

From: Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model

Fig. 2

AHCY copy number gain in the DZNep-resistant clone. a Log2 copy ratio plot of copy number variation regions in BLUE-1R10 in relation to BLUE-1 K10. The gray dots represent copy ratio values across different bins, the orange line shows segments and the yellow vertical lines indicate the respective genes. b Evolution of AHCY copy number in the resistant clone. Genomic DNA from the cell lines was subjected to the TaqMan copy number assay (ID: Hs02422126_cn). The real-time PCR read-out and copy number was analyzed with the CopyCaller software. A human tonsil DNA sample was used as a calibrator for the TaqMan copy number assay. c CNV plots calculated from global DNA methylation array data. Chromosome 20 locus on BLUE-1, BLUE-K10 and BLUE-1R10 was analyzed for variations in AHCY copy number. The y-axis represent the log2 copy number ratio (CNR). Amplifications represent positive deviations from the baseline while losses indicate negative deviations from the baseline (0.0). Encircled in red, shows AHCY copy number gain in BLUE-1R10

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