The role of human papillomavirus genotyping for detecting high-grade intraepithelial neoplasia or cancer in HPV-positive women with normal cytology: a study from a hospital in northeastern China

Table 2 Comparison of the proportions of HSIL+ among different age groups and hrHPV genotypes in hrHPV positive women with normal cytology who received colposcopy

		No. of hrHPV positive women with normal cytology who received colposcopy, n = 2665	No. of histological HSIL+	Percentages of HSIL+	χ² value	P value
Age groups	25–34	923	61	6.6	2.81	0.42
	35–44	975	84	8.6
	45–54	585	46	7.9
	55–65	182	13	7.1
HPV infection	single	2296	165	7.2	5.15	0.03
HPV infection	multiple	369	39	10.6
hrHPV genotype	16	801	119	14.9	82.37*	< 0.001*
	18	206	12	5.8		< 0.001^a
	31	142	15	10.6		0.19^a	0.15^b	0.86^c
	33	187	22	11.8		0.30^a	0.047^b
	35	21	0	0
	39	155	5	3.2
	45	43	2	4.7
	51	93	4	4.3
	52	362	28	7.7		0.001^a	0.50^b	0.19^c
	53	349	10	2.9		< 0.001^a
	56	34	0	0
	58	414	26	6.3		< 0.001^a	1.00^b	0.03^c
	59	65	1	1.5
	66	131	7	5.3
	68	105	4	3.8

Note *among hrHPV genotypes, ^acompared to HPV16, ^bcompared to HPV18, ^ccompared to HPV33

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