TY - JOUR AU - Bray, F. AU - Ferlay, J. AU - Soerjomataram, I. AU - Siegel, R. L. AU - Torre, L. A. AU - Jemal, A. PY - 2018 DA - 2018// TI - Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries JO - CA Cancer J Clin VL - 68 UR - https://doi.org/10.3322/caac.21492 DO - 10.3322/caac.21492 ID - Bray2018 ER - TY - JOUR AU - Siegel, R. L. AU - Miller, K. D. AU - Jemal, A. PY - 2015 DA - 2015// TI - Cancer statistics, 2015 JO - CA Cancer J Clin VL - 65 UR - https://doi.org/10.3322/caac.21254 DO - 10.3322/caac.21254 ID - Siegel2015 ER - TY - JOUR AU - Ryan, D. P. AU - Hong, T. S. AU - Bardeesy, N. PY - 2014 DA - 2014// TI - Pancreatic adenocarcinoma JO - N Engl J Med VL - 371 UR - https://doi.org/10.1056/NEJMra1404198 DO - 10.1056/NEJMra1404198 ID - Ryan2014 ER - TY - JOUR AU - Conroy, T. AU - Desseigne, F. AU - Ychou, M. AU - Bouche, O. AU - Guimbaud, R. AU - Becouarn, Y. PY - 2011 DA - 2011// TI - FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer JO - N Engl J Med VL - 364 UR - https://doi.org/10.1056/NEJMoa1011923 DO - 10.1056/NEJMoa1011923 ID - Conroy2011 ER - TY - JOUR AU - Collisson, E. A. AU - Sadanandam, A. AU - Olson, P. AU - Gibb, W. J. AU - Truitt, M. AU - Gu, S. PY - 2011 DA - 2011// TI - Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy JO - Nat Med VL - 17 UR - https://doi.org/10.1038/nm.2344 DO - 10.1038/nm.2344 ID - Collisson2011 ER - TY - JOUR AU - Noll, E. M. AU - Eisen, C. AU - Stenzinger, A. AU - Espinet, E. AU - Muckenhuber, A. AU - Klein, C. PY - 2016 DA - 2016// TI - CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma JO - Nat Med VL - 22 UR - https://doi.org/10.1038/nm.4038 DO - 10.1038/nm.4038 ID - Noll2016 ER - TY - JOUR AU - Duconseil, P. AU - Gilabert, M. AU - Gayet, O. AU - Loncle, C. AU - Moutardier, V. AU - Turrini, O. PY - 2015 DA - 2015// TI - Transcriptomic analysis predicts survival and sensitivity to anticancer drugs of patients with a pancreatic adenocarcinoma JO - Am J Pathol VL - 185 UR - https://doi.org/10.1016/j.ajpath.2014.11.029 DO - 10.1016/j.ajpath.2014.11.029 ID - Duconseil2015 ER - TY - JOUR AU - Moreira, L. AU - Bakir, B. AU - Chatterji, P. AU - Dantes, Z. AU - Reichert, M. AU - Rustgi, A. K. PY - 2018 DA - 2018// TI - Pancreas 3D Organoids: current and future aspects as a research platform for personalized medicine in pancreatic Cancer JO - Cell Mol Gastroenterol Hepatol VL - 5 UR - https://doi.org/10.1016/j.jcmgh.2017.12.004 DO - 10.1016/j.jcmgh.2017.12.004 ID - Moreira2018 ER - TY - JOUR AU - Huang, L. AU - Holtzinger, A. AU - Jagan, I. AU - BeGora, M. AU - Lohse, I. AU - Ngai, N. PY - 2015 DA - 2015// TI - Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids JO - Nat Med VL - 21 UR - https://doi.org/10.1038/nm.3973 DO - 10.1038/nm.3973 ID - Huang2015 ER - TY - JOUR AU - Olive, P. L. AU - Durand, R. E. PY - 1994 DA - 1994// TI - Drug and radiation resistance in spheroids: cell contact and kinetics JO - Cancer Metastasis Rev VL - 13 UR - https://doi.org/10.1007/BF00689632 DO - 10.1007/BF00689632 ID - Olive1994 ER - TY - JOUR AU - Mitra, A. AU - Mishra, L. AU - Li, S. PY - 2013 DA - 2013// TI - Technologies for deriving primary tumor cells for use in personalized cancer therapy JO - Trends Biotechnol VL - 31 UR - https://doi.org/10.1016/j.tibtech.2013.03.006 DO - 10.1016/j.tibtech.2013.03.006 ID - Mitra2013 ER - TY - JOUR AU - Elsasser, H. P. AU - Lehr, U. AU - Agricola, B. AU - Kern, H. F. PY - 1992 DA - 1992// TI - Establishment and characterisation of two cell lines with different grade of differentiation derived from one primary human pancreatic adenocarcinoma JO - Virchows Arch B Cell Pathol Incl Mol Pathol VL - 61 UR - https://doi.org/10.1007/BF02890431 DO - 10.1007/BF02890431 ID - Elsasser1992 ER - TY - JOUR AU - Wennerstrom, A. B. AU - Lothe, I. M. AU - Sandhu, V. AU - Kure, E. H. AU - Myklebost, O. AU - Munthe, E. PY - 2014 DA - 2014// TI - Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0103873 DO - 10.1371/journal.pone.0103873 ID - Wennerstrom2014 ER - TY - JOUR AU - Goodspeed, A. AU - Heiser, L. M. AU - Gray, J. W. AU - Costello, J. C. PY - 2016 DA - 2016// TI - Tumor-derived cell lines as molecular models of Cancer pharmacogenomics JO - Mol Cancer Res VL - 14 UR - https://doi.org/10.1158/1541-7786.MCR-15-0189 DO - 10.1158/1541-7786.MCR-15-0189 ID - Goodspeed2016 ER - TY - JOUR AU - Gillet, J. P. AU - Calcagno, A. M. AU - Varma, S. AU - Marino, M. AU - Green, L. J. AU - Vora, M. I. PY - 2011 DA - 2011// TI - Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance JO - Proc Natl Acad Sci U S A VL - 108 UR - https://doi.org/10.1073/pnas.1111840108 DO - 10.1073/pnas.1111840108 ID - Gillet2011 ER - TY - JOUR AU - Ruckert, F. AU - Aust, D. AU - Bohme, I. AU - Werner, K. AU - Brandt, A. AU - Diamandis, E. P. PY - 2012 DA - 2012// TI - Five primary human pancreatic adenocarcinoma cell lines established by the outgrowth method JO - J Surg Res VL - 172 UR - https://doi.org/10.1016/j.jss.2011.04.021 DO - 10.1016/j.jss.2011.04.021 ID - Ruckert2012 ER - TY - JOUR AU - Longati, P. AU - Jia, X. AU - Eimer, J. AU - Wagman, A. AU - Witt, M. R. AU - Rehnmark, S. PY - 2013 DA - 2013// TI - 3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing JO - BMC Cancer VL - 13 UR - https://doi.org/10.1186/1471-2407-13-95 DO - 10.1186/1471-2407-13-95 ID - Longati2013 ER - TY - JOUR AU - Horning, J. L. AU - Sahoo, S. K. AU - Vijayaraghavalu, S. AU - Dimitrijevic, S. AU - Vasir, J. K. AU - Jain, T. K. PY - 2008 DA - 2008// TI - 3-D tumor model for in vitro evaluation of anticancer drugs JO - Mol Pharm VL - 5 UR - https://doi.org/10.1021/mp800047v DO - 10.1021/mp800047v ID - Horning2008 ER - TY - JOUR AU - Boj, S. F. AU - Hwang, C. I. AU - Baker, L. A. AU - Chio, I. I. AU - Engle, D. D. AU - Corbo, V. PY - 2015 DA - 2015// TI - Organoid models of human and mouse ductal pancreatic cancer JO - Cell. VL - 160 UR - https://doi.org/10.1016/j.cell.2014.12.021 DO - 10.1016/j.cell.2014.12.021 ID - Boj2015 ER - TY - JOUR AU - Kang, Y. AU - Zhang, R. AU - Suzuki, R. AU - Li, S. Q. AU - Roife, D. AU - Truty, M. J. PY - 2015 DA - 2015// TI - Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype JO - Lab Investig VL - 95 UR - https://doi.org/10.1038/labinvest.2014.143 DO - 10.1038/labinvest.2014.143 ID - Kang2015 ER - TY - JOUR AU - Lee, G. Y. AU - Kenny, P. A. AU - Lee, E. H. AU - Bissell, M. J. PY - 2007 DA - 2007// TI - Three-dimensional culture models of normal and malignant breast epithelial cells JO - Nat Methods VL - 4 UR - https://doi.org/10.1038/nmeth1015 DO - 10.1038/nmeth1015 ID - Lee2007 ER - TY - JOUR AU - Feig, C. AU - Gopinathan, A. AU - Neesse, A. AU - Chan, D. S. AU - Cook, N. AU - Tuveson, D. A. PY - 2012 DA - 2012// TI - The pancreas cancer microenvironment JO - Clin Cancer Res VL - 18 UR - https://doi.org/10.1158/1078-0432.CCR-11-3114 DO - 10.1158/1078-0432.CCR-11-3114 ID - Feig2012 ER - TY - JOUR AU - Neesse, A. AU - Michl, P. AU - Frese, K. K. AU - Feig, C. AU - Cook, N. AU - Jacobetz, M. A. PY - 2011 DA - 2011// TI - Stromal biology and therapy in pancreatic cancer JO - Gut. VL - 60 UR - https://doi.org/10.1136/gut.2010.226092 DO - 10.1136/gut.2010.226092 ID - Neesse2011 ER - TY - JOUR AU - Shields, M. A. AU - Dangi-Garimella, S. AU - Redig, A. J. AU - Munshi, H. G. PY - 2012 DA - 2012// TI - Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression JO - Biochem J VL - 441 UR - https://doi.org/10.1042/BJ20111240 DO - 10.1042/BJ20111240 ID - Shields2012 ER - TY - JOUR AU - Golan, T. AU - Atias, D. AU - Barshack, I. AU - Avivi, C. AU - Goldstein, R. S. AU - Berger, R. PY - 2014 DA - 2014// TI - Ascites-derived pancreatic ductal adenocarcinoma primary cell cultures as a platform for personalised medicine JO - Br J Cancer VL - 110 UR - https://doi.org/10.1038/bjc.2014.123 DO - 10.1038/bjc.2014.123 ID - Golan2014 ER - TY - JOUR AU - Tsai, S. AU - McOlash, L. AU - Palen, K. AU - Johnson, B. AU - Duris, C. AU - Yang, Q. PY - 2018 DA - 2018// TI - Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models JO - BMC Cancer VL - 18 UR - https://doi.org/10.1186/s12885-018-4238-4 DO - 10.1186/s12885-018-4238-4 ID - Tsai2018 ER - TY - JOUR AU - McCarthy, R. C. AU - Breite, A. G. AU - Green, M. L. AU - Dwulet, F. E. PY - 2011 DA - 2011// TI - Tissue dissociation enzymes for isolating human islets for transplantation: factors to consider in setting enzyme acceptance criteria JO - Transplantation. VL - 91 UR - https://doi.org/10.1097/TP.0b013e3181ffff7d DO - 10.1097/TP.0b013e3181ffff7d ID - McCarthy2011 ER - TY - JOUR AU - Volovitz, I. AU - Shapira, N. AU - Ezer, H. AU - Gafni, A. AU - Lustgarten, M. AU - Alter, T. PY - 2016 DA - 2016// TI - A non-aggressive, highly efficient, enzymatic method for dissociation of human brain-tumors and brain-tissues to viable single-cells JO - BMC Neurosci VL - 17 UR - https://doi.org/10.1186/s12868-016-0262-y DO - 10.1186/s12868-016-0262-y ID - Volovitz2016 ER - TY - JOUR AU - Cassiman, J. J. AU - Brugmans, M. AU - Berghe, H. PY - 1981 DA - 1981// TI - Growth and surface properties of dispase dissociated human fibroblasts JO - Cell Biol Int Rep VL - 5 UR - https://doi.org/10.1016/0309-1651(81)90020-5 DO - 10.1016/0309-1651(81)90020-5 ID - Cassiman1981 ER - TY - JOUR AU - Chen, R. L. AU - James, R. F. PY - 2001 DA - 2001// TI - Characterization of an important enzymatic component in collagenase that is essential for the effective digestion of the human and porcine pancreas JO - Cell Transplant VL - 10 UR - https://doi.org/10.3727/000000001783986189 DO - 10.3727/000000001783986189 ID - Chen2001 ER - TY - JOUR AU - Nikolic, D. M. AU - Djordjevic, P. B. AU - Sreckovic, V. D. AU - Paunovic, I. AU - Kalezic, N. AU - Popovic, S. PY - 2010 DA - 2010// TI - Comparative analysis of collagenase XI and liberase H1 for the isolation of human pancreatic islets JO - Hepatogastroenterology. VL - 57 ID - Nikolic2010 ER - TY - JOUR AU - Lee, J. K. AU - Bloom, J. AU - Zubeldia-Plazaola, A. AU - Garbe, J. C. AU - Stampfer, M. R. AU - LaBarge, M. A. PY - 2018 DA - 2018// TI - Different culture media modulate growth, heterogeneity, and senescence in human mammary epithelial cell cultures JO - PLoS One VL - 13 UR - https://doi.org/10.1371/journal.pone.0204645 DO - 10.1371/journal.pone.0204645 ID - Lee2018 ER - TY - JOUR AU - Huch, M. AU - Bonfanti, P. AU - Boj, S. F. AU - Sato, T. AU - Loomans, C. J. AU - Wetering, M. PY - 2013 DA - 2013// TI - Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis JO - EMBO J VL - 32 UR - https://doi.org/10.1038/emboj.2013.204 DO - 10.1038/emboj.2013.204 ID - Huch2013 ER - TY - JOUR AU - Haramis, A. P. AU - Begthel, H. AU - Born, M. AU - Es, J. AU - Jonkheer, S. AU - Offerhaus, G. J. PY - 2004 DA - 2004// TI - De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine JO - Science. VL - 303 UR - https://doi.org/10.1126/science.1093587 DO - 10.1126/science.1093587 ID - Haramis2004 ER - TY - JOUR AU - Zhao, J. AU - Wang, Y. AU - Wu, X. PY - 2018 DA - 2018// TI - HMGN5 promotes proliferation and invasion via the activation of Wnt/beta-catenin signaling pathway in pancreatic ductal adenocarcinoma JO - Oncol Lett VL - 16 ID - Zhao2018 ER - TY - JOUR AU - Hezel, A. F. AU - Kimmelman, A. C. AU - Stanger, B. Z. AU - Bardeesy, N. AU - Depinho, R. A. PY - 2006 DA - 2006// TI - Genetics and biology of pancreatic ductal adenocarcinoma JO - Genes Dev VL - 20 UR - https://doi.org/10.1101/gad.1415606 DO - 10.1101/gad.1415606 ID - Hezel2006 ER - TY - JOUR AU - Claassen, D. A. AU - Desler, M. M. AU - Rizzino, A. PY - 2009 DA - 2009// TI - ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells JO - Mol Reprod Dev VL - 76 UR - https://doi.org/10.1002/mrd.21021 DO - 10.1002/mrd.21021 ID - Claassen2009 ER - TY - JOUR AU - Ostrom, M. AU - Loffler, K. A. AU - Edfalk, S. AU - Selander, L. AU - Dahl, U. AU - Ricordi, C. PY - 2008 DA - 2008// TI - Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells JO - PLoS One VL - 3 UR - https://doi.org/10.1371/journal.pone.0002841 DO - 10.1371/journal.pone.0002841 ID - Ostrom2008 ER - TY - JOUR AU - Eckerle, I. AU - Ehlen, L. AU - Kallies, R. AU - Wollny, R. AU - Corman, V. M. AU - Cottontail, V. M. PY - 2014 DA - 2014// TI - Bat airway epithelial cells: a novel tool for the study of zoonotic viruses JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0084679 DO - 10.1371/journal.pone.0084679 ID - Eckerle2014 ER - TY - JOUR AU - Kim, M. J. AU - Kim, M. S. AU - Kim, S. J. AU - An, S. AU - Park, J. AU - Park, H. PY - 2017 DA - 2017// TI - Establishment and characterization of 6 novel patient-derived primary pancreatic ductal adenocarcinoma cell lines from Korean pancreatic cancer patients JO - Cancer Cell Int VL - 17 UR - https://doi.org/10.1186/s12935-017-0416-8 DO - 10.1186/s12935-017-0416-8 ID - Kim2017 ER - TY - JOUR AU - Gage, B. K. AU - Webber, T. D. AU - Kieffer, T. J. PY - 2013 DA - 2013// TI - Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0082076 DO - 10.1371/journal.pone.0082076 ID - Gage2013 ER - TY - JOUR AU - Olivares, O. AU - Mayers, J. R. AU - Gouirand, V. AU - Torrence, M. E. AU - Gicquel, T. AU - Borge, L. PY - 2017 DA - 2017// TI - Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions JO - Nat Commun VL - 8 UR - https://doi.org/10.1038/ncomms16031 DO - 10.1038/ncomms16031 ID - Olivares2017 ER - TY - JOUR AU - Baker, L. A. AU - Tiriac, H. AU - Tuveson, D. A. PY - 1882 DA - 1882// TI - Generation and culture of human pancreatic ductal adenocarcinoma Organoids from resected tumor specimens JO - Methods Mol Biol VL - 2019 ID - Baker1882 ER - TY - JOUR AU - Schilsky, R. L. PY - 2010 DA - 2010// TI - Personalized medicine in oncology: the future is now JO - Nat Rev Drug Discov VL - 9 UR - https://doi.org/10.1038/nrd3181 DO - 10.1038/nrd3181 ID - Schilsky2010 ER -