Table 3 Comparison of polymorphisms between colorectal cancer patients and controls
From: Association of DNA repair gene variants with colorectal cancer: risk, toxicity, and survival
| Total, n (%) | Patients, n (%) | Controls, n (%) | Odds ratio (95% confidence interval) | p | |
|---|---|---|---|---|---|
| XRCC1-rs25487 | |||||
| G/G | 381 (42.8) | 253 (42.9) | 128 (42.7) | ||
| G/A + A/A | 509 (57.2) | 337 (57.1) | 172 (57.3) | 1.0 (0.7–1.3) | 0.95 |
| ERCC1-rs11615 | |||||
| T/T | 359 (40.8) | 237 (40.9) | 122 (40.7) | ||
| C/T + C/C | 521 (59.2) | 343 (59.1) | 178 (59.3) | 1.0 (0.7–1.3) | 0.95 |
| ERCC2-rs238406 | |||||
| C/C | 248 (28.5) | 178 (31.1) | 70 (23.6) | ||
| C/A + A/A | 621 (71.5) | 394 (68.9) | 227 (76.4) | 1.5 (1.1–2.0) | 0.01 |
| ERCC2-rs13181 | |||||
| A/C + C/C | 518 (59.2) | 362 (62.3) | 156 (53.1) | ||
| A/A | 357 (40.8) | 219 (37.7) | 138 (46.9) | 1.4 (1.0–1.9) | 0.009 |
| ERCC2-rs238406 AND ERCC2-rs13181 | |||||
| Unfavourable: [ERCC2-rs238406 C/C] AND [ERCC2-rs13181 A/C + C/C] | 227 (25.3) | 172 (28.9) | 55 (18.2) | ||
| Favourable: [ERCC2-rs238406 C/A + A/A] AND/OR [ERCC2-rs13181 A/A] | 670 (74.7) | 424 (71.1) | 246 (81.7) | 1.8 (1.3–2.6) | 0.001 |