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Table 2 Cox regression analysis of LRIG1 loss, normal, and gain adjusted for all variables in all patients

From: LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer

Tumor characteristicOverall survivalMetastasis-free survival
Hazard ratio
(95% CI)
P-valueHazard ratio
(95% CI)
P-value
Age at diagnosis
  ≤ 50 yearsReference   
  > 50 years2.633 (1.802–3.848)< 0.0011.306 (0.828–2.060)0.251
Tumor subtype
ERBB2-, ER/PR+Reference   
ERBB2+, ER/PR-1.558 (1.003–2.420)0.0491.915 (1.077–3.405)0.027
ERBB2+, ER/PR+1.563 (0.974–2.507)0.0641.983 (1.101–3.573)0.023
ERBB2-, ER/PR-1.384 (0.939–2.038)0.11.583 (0.936–2.679)0.087
Grade
 Low (1 or 2)Reference   
 High (3)1.0 (1.0–1.0)0.7101.583 (0.936–2.679)0.087
Tumor size
  ≤ 20 mmReference   
  > 20 mm1.427 (1.067–1.908)0.0171.151 (0.751–1.762)0.519
Nodal status
 NegativeReference   
 Positive2.592 (1.840–3.651)< 0.0013.435 (2.206–5.347)< 0.001
LRIG1copy number
 NormalReference   
 Loss0.964 (0.668–1.393)0.8471.115 (0.690–1.803)0.657
 Gain0.837 (0.550–1.274)0.4071.041 (0.585–1.852)0.892