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Table 1 LRIG1 copy number ratios and clinicopathological characteristics of the breast cancer cohort

From: LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer

CharacteristicLossaNormalaGainaP-value*
Number of patients (N = 42377 (18.2%)293 (69.3%)53 (12.5%) 
Age at diagnosis (years; mean ± SD)55.7 ± 13.360.1 ± 11.5462.5 ± 13.42 
Age ≤ 60 (N = 211)46 (21.8%)142 (67.3%)23 (10.9%)0.125
Age > 60 (N = 212)31 (14.6%)151 (71.2%)30 (14.2%) 
Steroid receptor status<  0.001
 Negative (N = 117)39 (33.3%)65 (55.6%)13 (11.1%) 
 Positive (N = 306)38 (12.4%)228 (74.5%)40 (13.1%) 
ERBB2status0.002
 Negative (N = 336)50 (14.9%)245 (72.9%)41 (12.2%) 
 Positive (N = 87)27 (31.0%)48 (55.2%)12 (13.8%) 
Tumor subtype< 0.001
ERBB2+, ER/PR- (N = 45)16 (35.6%)23 (51.1%)6 (13.3%) 
ERBB2+, ER/PR+ (N = 42)11 (26.2%)25 (59.5%)6 (14.3%) 
ERBB2-, ER/PR+ (N = 264)27 (10.2%)203 (76.9%)34 (12.9%) 
ERBB2-, ER/PR- (N = 72)23 (31.9%)42 (58.3%)7 (9.7%) 
Disease stage (N = 278; missing data = 145)0.151
 I (N = 109)18 (16.5%)84 (77.1%)7 (6.4%) 
 II (N = 131)28 (21.4%)85 (64.9%)18 (13.7%) 
 III (N = 7)1 (14.3%)5 (71.4%)1 (14.3%) 
 IV (N = 31)6 (19.4%)17 (54.8%)8 (25.8%) 
Tumor grade (N = 363, missing data = 60)0.004
 I (N = 31)1 (3.2%)25 (80.6%)5 (16.1%) 
 II (N = 137)15 (10.9%)104 (75.9%)18 (13.1%) 
 III (N = 195)50 (25.6%)120 (61.5%)25 (12.8%) 
Tumor size (N = 329, missing data = 94)0.158
 Size ≤20 mm (N = 154)29 (18.8%)111 (72.1%)14 (9.1%) 
 Size > 20 mm (N = 175)37 (21.1%)111 (63.4%)27 (15.4%) 
Nodal status (N = 360, missing data = 63)0.001
 Negative (N = 279)43 (15.4%)207 (74.2%)29 (10.4%) 
 Positive (N = 81)24 (29.6%)43 (53.1%)14 (17.3%) 
Tumor types0.041
 Ductal (N = 354)66 (18.6%)237 (66.9%)51 (14.4%) 
 Lobular (N = 35)5 (14.3%)30 (85.7%)0 (0.0%) 
 Others (N = 34)6 (17.6%)26 (76.5%)2 (5.9%) 
  1. aLRIG1/CYP1B1 ratio < 0.85, loss; 0.85–1.15, normal; > 1.15, gain
  2. *The overall P values are from comparisons between all LRIG1 loss, LRIG1 normal and LRIG1 gain groups. Significance was calculated by the 2-sided Fisher’s exact test