Parameters | Median (months) | 95% CI | P value | Hazard ratio | 95% CI | P value |
---|---|---|---|---|---|---|
Age | .821 | – | ||||
≦65 (n = 74) | 3.8 | 2.7–4.9 | ||||
> 65 (n = 44) | 3.3 | 2.3–4.2 | ||||
Gender | .540 | – | ||||
Male (n = 58) | 2.8 | 2.2–3.4 | ||||
Female (n = 60) | 4.0 | 2.8–5.3 | ||||
ICD-10 cancer site | .011 | |||||
C22.1 – ICCA (n = 86) | 3.9 | 2.6–5.2 | 0.877 | 0.321–2.397 | .799 | |
C23/C24.9 –GB/others (n = 18) | 2.7 | 2.4–3.0 | 1.568 | 0.510–4.819 | .433 | |
C24.0 – ECCA (n = 9) | 8.0 | 0.0–24.4 | 1 | |||
C24.1 – Ampullary (n = 5) | 3.3 | 1.7–4.8 | 1.519 | 0.378–6.110 | .556 | |
Performance status | .260 | – | ||||
0/1 (n = 102) | 3.8 | 2.7–4.9 | ||||
2/3 (n = 16) | 2.7 | 1.8–3.7 | ||||
NLR | .020 | |||||
≦7.45 (n = 100) | 3.8 | 2.8–4.8 | 1 | |||
> 7.45 (n = 18) | 2.4 | 1.4–3.3 | 1.982 | 1.040–3.777 | .038 | |
MLR | .028 | |||||
≦0.28 (n = 40) | 5.9 | 4.3–7.4 | 1 | |||
> 0.28 (n = 78) | 2.9 | 2.5–3.3 | 1.263 | 0.737–2.162 | .396 | |
PLR | .396 | – | ||||
≦136.4 (n = 47) | 4.8 | 2.9–6.8 | ||||
> 136.4 (n = 71) | 3.1 | 2.7–3.5 | ||||
Albumin (g/dL) | .777 | – | ||||
≦3.5 (n = 33) | 3.1 | 2.6–3.6 | ||||
> 3.5 (n = 72) | 3.9 | 2.8–4.9 | ||||
ALT (U/L) | .484 | – | ||||
≦36 (n = 68) | 3.2 | 2.3–4.0 | ||||
> 36 (n = 49) | 4.3 | 2.8–5.7 | ||||
Bilirubin (mg/dL) | .622 | – | ||||
≦1.3 (n = 89) | 3.8 | 2.6–5.0 | ||||
> 1.3 (n = 28) | 3.3 | 2.4–4.1 | ||||
ALP (U/L) | .060 | – | ||||
≦94 (n = 30) | 5.9 | 2.5–9.2 | ||||
> 94 (n = 82) | 2.8 | 2.4–3.3 | ||||
Creatinine (mg/dL) | .612 | – | ||||
≦1.27 (n = 115) | 3.6 | 2.6–4.6 | ||||
> 1.27 (n = 3) | 2.7 | 0.0–6.7 | ||||
CA19–9 (U/mL) | .263 | – | ||||
≦37 (n = 35) | 2.9 | 2.3–3.4 | ||||
> 37 (n = 82) | 4.3 | 2.7–5.9 | ||||
CEA (ng/mL) | .347 | – | ||||
≦5 (n = 64) | 4.3 | 3.0–5.7 | ||||
> 5 (n = 54) | 3.2 | 2.7–3.6 | ||||
Biliary drainage | .047 | |||||
None (n = 88) | 3.2 | 2.4–4.0 | 1.396 | 0.497–3.921 | .527 | |
Internal drainage(n = 8) | 7.6 | 3.2–12.1 | 1 | |||
PTCD (n = 19) | 3.4 | 2.8–4.0 | 0.711 | 0.244–2.066 | .531 | |
Both (n = 3) | 1.3 | 0.5–2.1 | 8.710 | 1.831–41.445 | .007 | |
Tumor involvement | ||||||
Primary tumor | .081 | – | ||||
No (n = 8) | 2.6 | 2.1–3.1 | ||||
Yes (n = 110) | 3.8 | 2.7–4.8 | ||||
Regional LAP | .679 | – | ||||
No (n = 42) | 3.9 | 2.6–5.1 | ||||
Yes (n = 76) | 3.2 | 2.3–4.1 | ||||
Lung | <.001 | |||||
No (n = 95) | 4.3 | 3.0–5.6 | 1 | |||
Yes (n = 23) | 2.6 | 2.2–3.1 | 1.678 | 0.905–3.112 | .101 | |
Bone | .181 | |||||
No (n = 105) | 3.8 | 2.7–4.8 | ||||
Yes (n = 13) | 3.4 | 2.3–4.5 | ||||
Liver | .034 | |||||
No (n = 69) | 4.3 | 2.2–6.3 | 1 | |||
Yes (n = 49) | 3.2 | 2.1–4.2 | 1.232 | 0.759–1.998 | .398 | |
Peritoneum | .138 | – | ||||
No (n = 96) | 3.9 | 2.5–5.2 | ||||
Yes (n = 22) | 3.1 | 2.5–3.7 | ||||
Distant LAP | .785 | – | ||||
No (n = 102) | 3.4 | 2.3–4.5 | ||||
Yes (n = 16) | 3.6 | 2.5–4.7 | ||||
Tumor Response | <.0001 | |||||
CR/RR (n = 15) | 14.1 | 7.9–20.2 | 1 | |||
SD (n = 41) | 7.6 | 6.4–8.8 | 1.819 | 0.824–4.015 | .139 | |
PD (n = 48) | 2.5 | 2.4–2.7 | 55.556 | 19.467–158.550 | <.0001 | |
N/A (n = 14) | 1.3 | 0.8–1.9 | 63.905 | 20.396–200.232 | <.0001 |