Table 3 The association between genes mutation with MSI status of CRC with and without mucinous components
Gene mutation | CRC with mucinous components | CRC without mucinous components | ||||
|---|---|---|---|---|---|---|
MMR-deficient (n = 23) | MMR-proficient (n = 26) | MMR-deficient (n = 19) | MMR-proficient (n = 98) | |||
KRAS | 8 | 20 | p = 0.001 | 8 | 40 | |
BRAF | 15 | 4 | p = 0.001 | 6 | 7 | p = 0.007 |
APC | 3 | 9 | 5 | 37 | ||
TP53 | 1 | 10 | p < 0.05 | 5 | 61 | p < 0.05 |
PIK3CA | 9 | 7 | 7 | 20 | ||
SMAD4 | 2 | 7 | 1 | 8 | ||
PTEN | 6 | 2 | p = 0.125 | 2 | 4 | |
FBXW7 | 2 | 1 | 5 | 7 | ||