Disease-free survival as a surrogate endpoint for overall survival in adjuvant trials of pancreatic cancer: a meta-analysis of 20 randomized controlled trials

Table 3 Sensitivity analysis

	R² (95% CI)	P value	STE
Total population [5,6,7,8,9,10, 17,18,19,20,21,22,23,24, 34,35,36,37,38,39]			0.96
Sample size	0.80 (0.49 to 0.99)	< 0.001
Fixed effect	0.82 (0.52 to 0.99)	< 0.001
Random effect	0.82 (0.52 to 0.99)	< 0.001
Phase 3 trials [5,6,7,8,9,10, 18,19,20, 22, 34,35,36, 38, 39]			0.96
Sample size	0.82 (0.48 to 0.99)	< 0.001
Fixed effect	0.82 (0.49 to 0.99)	< 0.001
Random effect	0.83 (0.50 to 0.99)	< 0.001
Trials with overall included patients ≥ 200 [7, 10, 18,19,20, 36, 38, 39]			0.93
Sample size	0.85 (0.41 to 0.99)	< 0.001
Fixed effect	0.86 (0.41 to 0.99)	< 0.001
Random effect	0.87 (0.44 to 0.99)	< 0.001
Trials with median follow-up ≥ 24 months [6, 7, 9, 10, 18,19,20,21,22,23, 34, 36, 38, 39]			0.95
Sample size	0.80 (0.43 to 0.99)	< 0.001
Fixed effect	0.81 (0.45 to 0.99)	< 0.001
Random effect	0.80 (0.43 to 0.99)	< 0.001
Trials with adjuvant therapy versus observation [5,6,7,8,9, 20, 34, 35]			0.81
Sample size	0.68 (0.17 to 0.99)	0.006
Fixed effect	0.69 (0.18 to 0.99)	0.005
Random effect	0.73 (0.22 to 0.99)	0.003
Trials with adjuvant therapy versus adjuvant therapy [8, 17,18,19, 21,22,23,24, 36, 38, 39]			0.96
Sample size	0.90 (0.59 to 0.99)	< 0.001
Fixed effect	0.93 (0.66 to 0.99)	< 0.001
Random effect	0.89 (0.58 to 0.99)	< 0.001

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