Fig. 1

In vivo effect of continuous exposure to cetuximab on colorectal carcinomas patient-derived xenografts (PDX). PDX tumor growth curves of continuous passages was respectively shown in (a, b, c, d). Immune-deficient nu/nu mice (n = 3) bearing subcutaneous tumors were treated with 40 mg/kg Cetuximab or PBS twice weekly for 3–5 weeks. The tumor sizes were measured with calipers twice weekly