Table 4 Metabolic alterations in ERG Rearrangement-positive PC versus ERG Rearrangement-negative PC
Metabolite | Change in ERG-positive PC | Technique | BH p-valuea | BH p-value for mixed model | BH p-value for mixed model adjusted for Gleason score | BH p-value for mixed model adjusted for percentage of epithelium | BH p-value for mixed model adjusted for percentage of malignancy |
|---|---|---|---|---|---|---|---|
Glycerophosphocholine | ↓ | 1H HR MAS NMR | 7.05 × 10−3 | 4.50 × 10−01 | 7.69 × 10− 01 | 4.03 × 10− 01 | 3.79 × 10− 01 |
O-Phosphocholine | ↓ | 1H HR MAS NMR | 2.96 × 10− 2 | 5.43 × 10− 01 | 7.47 × 10− 01 | 5.31 × 10− 01 | 5.47 × 10− 01 |
Lysine | ↓ | 1H HR MAS NMR | 1.64 × 10− 2 | 8.85 × 10− 02 | 6.46 × 10− 01 | 1.05 × 10− 02 | 2.00 × 10− 02 |
Tyrosine | ↓ | 1H HR MAS NMR | 8.74 × 10− 3 | 1.54 × 10− 03 | 2.40 × 10− 01 | 1.54 × 10− 03 | 2.81 × 10− 03 |
Myo-inositol | ↑ | 1H HR MAS NMR | 4.73 × 10−3 | 3.00 × 10− 02 | 2.99 × 10− 01 | 5.09 × 10− 02 | 5.82 × 10− 02 |
Valine | ↓ | 1H HR MAS NMR | 1.81 × 10− 2 | 6.91 × 10− 02 | 6.46 × 10− 01 | 3.09 × 10− 02 | 3.54 × 10− 02 |
Phenylalanine | ↓ | 1H HR MAS NMR | 3.52 × 10− 2 | 1.34 × 10− 02 | 2.89 × 10− 01 | 1.39 × 10− 02 | 2.00 × 10− 02 |
Hypoxanthine | ↓ | 1H HR MAS NMR | 1.71 × 10− 2 | 8.23 × 10− 02 | 6.13 × 10− 01 | 7.59 × 10− 02 | 4.68 × 10− 02 |
Ascorbate | ↓ | 1H HR MAS NMR | 3.57 × 10− 2 | 3.20 × 10− 01 | 7.69 × 10− 01 | 4.03 × 10− 01 | 2.81 × 10− 01 |
Glutathione | ↓ | 1H HR MAS NMR | 3.57 × 10− 2 | 3.66 × 10− 01 | 7.95 × 10− 01 | 4.93 × 10− 01 | 4.03 × 10− 01 |
Aspartate | ↓ | 1H HR MAS NMR | 4.15 × 10− 2 | 2.74 × 10− 01 | 7.69 × 10− 01 | 2.92 × 10− 01 | 4.28 × 10− 01 |
Butyrylcarnitine | ↑ | LC-MS (+) | 6.90 × 10− 4 | 1.63 × 10− 01 | 3.46 × 10− 01 | 1.57 × 10− 01 | 1.57 × 10− 01 |
Myristoylcarnitine | ↑ | LC-MS (+) | 3.06 × 10− 4 | 8.85 × 10− 02 | 1.88 × 10− 01 | 5.99 × 10− 02 | 3.76 × 10− 02 |
Hexanoylcarnitine | ↑ | LC-MS (+) | 6.90 × 10− 4 | 2.30 × 10− 01 | 6.08 × 10− 01 | 2.50 × 10− 01 | 2.42 × 10− 01 |
Xanthine | ↑ | LC-MS (+) | 2.84 × 10−4 | 8.97 × 10− 04 | 3.42 × 10− 03 | 1.54 × 10− 03 | 2.81 × 10− 03 |
Acetylcarnitine | ↑ | LC-MS (+) | 3.46 × 10− 4 | 9.15 × 10− 01 | 3.31 × 10− 01 | 9.77 × 10− 02 | 1.12 × 10− 01 |
Adenine | ↑ | LC-MS (+) | 1.55 × 10− 3 | 1.75 × 10− 01 | 2.89 × 10− 01 | 1.69 × 10− 01 | 1.57 × 10− 01 |
Palmitoylcarnitine | ↑ | LC-MS (+) | 2.76 × 10− 3 | 1.78 × 10− 01 | 2.89 × 10− 01 | 1.26 × 10− 01 | 1.27 × 10− 01 |
Sphingosine | ↓ | LC-MS (+) | 8.34 × 10− 3 | 2.75 × 10− 01 | 6.13 × 10− 01 | 3.32 × 10− 01 | 3.08 × 10− 01 |
Dodecanoylcarnitine | ↑ | LC-MS (+) | 2.58 × 10− 3 | 2.67 × 10− 01 | 4.73 × 10− 01 | 2.92 × 10− 01 | 2.34 × 10− 01 |
Oleoylcarnitine | ↑ | LC-MS (+) | 1.70 × 10− 2 | 4.77 × 10− 01 | 5.60 × 10− 01 | 3.61 × 10− 01 | 3.36 × 10− 01 |
Stearoylcarnitine | ↑ | LC-MS (+) | 4.26 × 10− 3 | 1.81 × 10− 01 | 2.89 × 10− 01 | 1.25 × 10− 01 | 1.27 × 10− 01 |
Inosine | ↑ | LC-MS (+) | 8.44 × 10− 4 | 1.78 × 10− 01 | 4.73 × 10− 01 | 1.80 × 10− 01 | 1.89 × 10− 01 |
Propionylcarnitine | ↑ | LC-MS (+) | 2.90 × 10−2 | 4.05 × 10− 01 | 7.35 × 10− 01 | 4.22 × 10− 01 | 4.03 × 10− 01 |
Uric acid | ↑ | LC-MS (+) | 2.16 × 10− 3 | 1.75 × 10− 01 | 4.73 × 10− 01 | 1.57 × 10− 01 | 1.83 × 10− 01 |