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Table 3 Metabolic alterations in high Gleason score (GS ≥ 7) to low Gleason score (GS = 6) prostate cancer

From: Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status

Metabolite Change in GS ≥ 7 Technique BH p-valuea BH p-value for Mixed Model BH p-value for Mixed Model adjusted for percentage of epithelium BH p-value for Mixed Model adjusted for percentage of malignancy BH p-value for Mixed Model adjusted for percentage of epithelium and malignancy
Glycerophosphorylcholine 1H HR MAS NMR 1.89 × 10−04 4.46 × 10− 2 2.94 × 10− 1 1.06 × 10− 1 2.07 × 10− 2
Phosphocholine 1H HR MAS NMR 3.10 × 10− 03 1.91 × 10− 2 4.23 × 10− 2 8.04 × 10− 2 2.07 × 10− 2
Hypoxanthine 1H HR MAS NMR 2.29 × 10− 05 3.51 × 10− 4 5.37 × 10− 2 9.01 × 10− 2 7.81 × 10− 4
Lysine 1H HR MAS NMR 1.89 × 10− 04 3.04 × 10− 4 4.43 × 10− 2 6.54 × 10− 2 2.68 × 10− 4
Glutamate 1H HR MAS NMR 2.95 × 10− 05 1.28 × 10− 4 2.30 × 10− 2 7.86 × 10− 2 3.33 × 10− 4
Threonine 1H HR MAS NMR 5.95 × 10− 03 4.34 × 10− 2 4.17 × 10− 1 3.28 × 10− 1 2.07 × 10− 2
Tyrosine 1H HR MAS NMR 9.99 × 10− 03 3.97 × 10− 3 4.71 × 10− 2 6.54 × 10− 2 1.72 × 10− 3
Valine 1H HR MAS NMR 6.90 × 10− 03 3.64 × 10− 3 4.23 × 10− 2 6.54 × 10− 2 3.54 × 10− 3
Ascorbate 1H HR MAS NMR 4.26 × 10− 03 1.78 × 10− 2 2.57 × 10− 1 3.44 × 10− 1 2.07 × 10− 2
Phenylalanine 1H HR MAS NMR 4.34 × 10− 02 3.52 × 10− 2 5.37 × 10− 2 9.01 × 10− 2 2.07 × 10− 2
α-Glucose 1H NMR 2.25 × 10− 02 2.02 × 10− 8 3.02 × 10− 3 1.42 × 10− 1 2.68 × 10− 4
Arginine 1H NMR 2.44 × 10− 03 2.02 × 10− 8 5.37 × 10− 2 9.01 × 10− 2 6.36 × 10− 7
Lipid (n) CH2 1H NMR 2.25 × 10− 02 4.34 × 10− 2 9.18 × 10− 1 6.14 × 10− 1 4.07 × 10− 3
2-Hydroxybutyrate 1H NMR 2.44 × 10− 03 1.39 × 10− 3 5.76 × 10− 1 1.42 × 10− 1 1.56 × 10− 4
Sphingosine LC-MS (+) 5.62 × 10− 03 2.73 × 10− 1 6.49 × 10− 1 6.75 × 10− 1 3.06 × 10− 1
Hexanoylcarnitine LC-MS (+) 5.62 × 10− 03 2.10 × 10− 1 3.53 × 10− 1 3.28 × 10− 1 2.37 × 10− 1
  1. BH Benjamini–Hochberg multiple testing correction; a nonparametric t-test