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Table 2 Metabolic alterations in prostate cancer tissues compared to benign prostate tissues

From: Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status

Metabolite Change in PC Technique BH p-valuea BH p-value for mixed model BH p-value for mixed model adjusted for percentage of epithelium BH p-value for mixed model adjusted for percentage of malignancy BH p-value for mixed model adjusted for percentage of epithelium and malignancy
Phosphocholine 1H HR MAS NMR 1.08 × 10− 07 2.53 × 10− 10 2.81 × 10− 08 1.22 × 10− 03 1.24 × 10− 04
Glutamate 1H HR MAS NMR 7.17 × 10− 07 2.26 × 10− 08 6.41 × 10− 07 5.91 × 10− 03 3.87 × 10− 04
Citrate 1H HR MAS NMR 6.66 × 10− 06 6.48 × 10− 08 1.97 × 10− 07 1.44 × 10−02 2.07 × 10− 02
Hypoxanthine 1H HR MAS NMR 4.68 × 10−08 1.58 × 10−08 1.11 × 10−05 5.91 × 10− 03 7.73 × 10− 05
Polyamines 1H HR MAS NMR 9.61 × 10− 05 6.16 × 10− 08 1.42 × 10−07 3.06 × 10− 03 1.22 × 10− 02
Inosine 1H HR MAS NMR 1.35 × 10− 05 1.07 × 10−04 5.06 × 10− 03 7.25 × 10− 02 1.02 × 10− 02
α-Glucose 1H NMR 8.89 × 10− 04 1.58 × 10− 08 2.09 × 10− 05 1.75 × 10− 02 1.24 × 10− 04
Nicotinamide adenine dinucleotide (NAD+) 1H NMR 3.17 × 10− 03 3.81 × 10− 07 7.77 × 10−06 3.06 × 10− 03 1.87 × 10− 04
Arginine 1H NMR 8.89 × 10− 04 2.98 × 10− 06 5.46 × 10− 02 3.77 × 10− 01 1.41 × 10− 04
Succinate/Malate 1H NMR 2.40 × 10− 02 6.80 × 10− 03 6.67 × 10− 01 4.38 × 10− 01 1.80 × 10− 03
Lysophosphatidylcholine 31P NMR 1.44 × 10− 04 1.87 × 10− 02 3.16 × 10− 01 6.53 × 10− 01 4.31 × 10− 02
Phosphatidylethanolamine 31P NMR 5.50 × 10− 03 4.82 × 10− 04 1.49 × 10− 03 1.05 × 10− 02 5.87 × 10− 03
Sphingomyelin 31P NMR 1.01 × 10− 03 4.22 × 10− 05 2.12 × 10− 04 8.34 × 10− 03 3.20 × 10− 03
Uracil LC-MS (+) 9.69 × 10− 05 2.98 × 10− 06 3.59 × 10− 05 1.71 × 10− 02 1.42 × 10− 03
Docosapentaenoic acid (22:5) LC-MS (−) 5.01 × 10− 05 3.81 × 10− 07 3.38 × 10− 04 1.44 × 10− 02 7.73 × 10− 05
Oleic acid (18:1) LC-MS (−) 9.32 × 10− 05 3.52 × 10− 06 1.09 × 10− 03 4.22 × 10− 03 9.63 × 10− 05
Linoleic acid (18:2) LC-MS (−) 2.29 × 10− 04 1.45 × 10− 05 3.14 × 10− 03 1.05 × 10− 02 1.53 × 10− 04
Docosahexaenoic acid (22:6) LC-MS (−) 1.25 × 10− 03 9.69 × 10− 04 7.92 × 10− 02 2.86 × 10− 02 7.66 × 10− 04
Maleic acid LC-MS (−) 9.32 × 10− 05 5.63 × 10− 07 2.96 × 10− 05 2.71 × 10− 01 6.19 × 10− 02
Malic acid (Fumarate) LC-MS (−) 2.92 × 10− 03 6.86 × 10− 03 3.20 × 10− 02 2.71 × 10− 01 3.90 × 10− 02
  1. BH Benjamini–Hochberg multiple testing correction; a nonparametric t-test