|
Metabolite
|
Change in PC
|
Technique
|
BH p-valuea
|
BH p-value for mixed model
|
BH p-value for mixed model adjusted for percentage of epithelium
|
BH p-value for mixed model adjusted for percentage of malignancy
|
BH p-value for mixed model adjusted for percentage of epithelium and malignancy
|
|---|
|
Phosphocholine
|
↑
|
1H HR MAS NMR
|
1.08 × 10− 07
|
2.53 × 10− 10
|
2.81 × 10− 08
|
1.22 × 10− 03
|
1.24 × 10− 04
|
|
Glutamate
|
↑
|
1H HR MAS NMR
|
7.17 × 10− 07
|
2.26 × 10− 08
|
6.41 × 10− 07
|
5.91 × 10− 03
|
3.87 × 10− 04
|
|
Citrate
|
↓
|
1H HR MAS NMR
|
6.66 × 10− 06
|
6.48 × 10− 08
|
1.97 × 10− 07
|
1.44 × 10−02
|
2.07 × 10− 02
|
|
Hypoxanthine
|
↑
|
1H HR MAS NMR
|
4.68 × 10−08
|
1.58 × 10−08
|
1.11 × 10−05
|
5.91 × 10− 03
|
7.73 × 10− 05
|
|
Polyamines
|
↓
|
1H HR MAS NMR
|
9.61 × 10− 05
|
6.16 × 10− 08
|
1.42 × 10−07
|
3.06 × 10− 03
|
1.22 × 10− 02
|
|
Inosine
|
↑
|
1H HR MAS NMR
|
1.35 × 10− 05
|
1.07 × 10−04
|
5.06 × 10− 03
|
7.25 × 10− 02
|
1.02 × 10− 02
|
|
α-Glucose
|
↓
|
1H NMR
|
8.89 × 10− 04
|
1.58 × 10− 08
|
2.09 × 10− 05
|
1.75 × 10− 02
|
1.24 × 10− 04
|
|
Nicotinamide adenine dinucleotide (NAD+)
|
↓
|
1H NMR
|
3.17 × 10− 03
|
3.81 × 10− 07
|
7.77 × 10−06
|
3.06 × 10− 03
|
1.87 × 10− 04
|
|
Arginine
|
↑
|
1H NMR
|
8.89 × 10− 04
|
2.98 × 10− 06
|
5.46 × 10− 02
|
3.77 × 10− 01
|
1.41 × 10− 04
|
|
Succinate/Malate
|
↑
|
1H NMR
|
2.40 × 10− 02
|
6.80 × 10− 03
|
6.67 × 10− 01
|
4.38 × 10− 01
|
1.80 × 10− 03
|
|
Lysophosphatidylcholine
|
↓
|
31P NMR
|
1.44 × 10− 04
|
1.87 × 10− 02
|
3.16 × 10− 01
|
6.53 × 10− 01
|
4.31 × 10− 02
|
|
Phosphatidylethanolamine
|
↑
|
31P NMR
|
5.50 × 10− 03
|
4.82 × 10− 04
|
1.49 × 10− 03
|
1.05 × 10− 02
|
5.87 × 10− 03
|
|
Sphingomyelin
|
↓
|
31P NMR
|
1.01 × 10− 03
|
4.22 × 10− 05
|
2.12 × 10− 04
|
8.34 × 10− 03
|
3.20 × 10− 03
|
|
Uracil
|
↑
|
LC-MS (+)
|
9.69 × 10− 05
|
2.98 × 10− 06
|
3.59 × 10− 05
|
1.71 × 10− 02
|
1.42 × 10− 03
|
|
Docosapentaenoic acid (22:5)
|
↑
|
LC-MS (−)
|
5.01 × 10− 05
|
3.81 × 10− 07
|
3.38 × 10− 04
|
1.44 × 10− 02
|
7.73 × 10− 05
|
|
Oleic acid (18:1)
|
↑
|
LC-MS (−)
|
9.32 × 10− 05
|
3.52 × 10− 06
|
1.09 × 10− 03
|
4.22 × 10− 03
|
9.63 × 10− 05
|
|
Linoleic acid (18:2)
|
↑
|
LC-MS (−)
|
2.29 × 10− 04
|
1.45 × 10− 05
|
3.14 × 10− 03
|
1.05 × 10− 02
|
1.53 × 10− 04
|
|
Docosahexaenoic acid (22:6)
|
↑
|
LC-MS (−)
|
1.25 × 10− 03
|
9.69 × 10− 04
|
7.92 × 10− 02
|
2.86 × 10− 02
|
7.66 × 10− 04
|
|
Maleic acid
|
↑
|
LC-MS (−)
|
9.32 × 10− 05
|
5.63 × 10− 07
|
2.96 × 10− 05
|
2.71 × 10− 01
|
6.19 × 10− 02
|
|
Malic acid (Fumarate)
|
↑
|
LC-MS (−)
|
2.92 × 10− 03
|
6.86 × 10− 03
|
3.20 × 10− 02
|
2.71 × 10− 01
|
3.90 × 10− 02
|
- BH Benjamini–Hochberg multiple testing correction; a nonparametric t-test
