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Table 3 Univariate and multivariate analysis for overall survival, progression free survival and response according to DPD

From: DPD status and fluoropyrimidines-based treatment: high activity matters too

Variable Univariate analysis Multivariate analysis
p-value HR [CI95] p-value HR [CI95]
DPD activity versus overall survivala
  < 0.30
  ≥ 0.30 0.0018 3.1 [1.50–6.50] 0.013 3.35 [1.27–8.86]
DPD activity versus progression free survivala
  < 0.30
  ≥ 0.30 0.0016 2.40 [1.40–4.00] < 0.001 3.15 [1.75–5.66]
DPD activity versus response to fluoropyrimidineb
  < 0.30    
  ≥ 0.30 0.022 0.34 [0.13–0.87] 0.033 0.33 [0.12–0.92]
  1. HR [CI95] Hazard ratio and confidence interval 95%
  2. a Cox proportional hazards model
  3. b Logistic regression model
  4. All variables associated with p < 0.10 in univariate analysis were included in a Cox regression or Logistic regression model. All models were stratified on cancer locations (digestive, breast, head and neck)