DPD status and fluoropyrimidines-based treatment: high activity matters too

BMC Cancer

Table 3 Univariate and multivariate analysis for overall survival, progression free survival and response according to DPD

Variable	Univariate analysis		Multivariate analysis
Variable	p-value	HR [CI95]	p-value	HR [CI95]
DPD activity versus overall survival^a
< 0.30	–	–	–	–
≥ 0.30	0.0018	3.1 [1.50–6.50]	0.013	3.35 [1.27–8.86]
DPD activity versus progression free survival^a
< 0.30	–	–	–	–
≥ 0.30	0.0016	2.40 [1.40–4.00]	< 0.001	3.15 [1.75–5.66]
DPD activity versus response to fluoropyrimidine^b
< 0.30	–
≥ 0.30	0.022	0.34 [0.13–0.87]	0.033	0.33 [0.12–0.92]

HR [CI95] Hazard ratio and confidence interval 95%
^a Cox proportional hazards model
^b Logistic regression model
All variables associated with p < 0.10 in univariate analysis were included in a Cox regression or Logistic regression model. All models were stratified on cancer locations (digestive, breast, head and neck)

ISSN: 1471-2407