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Table 5 Frequency of adverse drug reactions in different variants of IVS14 + 1G > A

From: Evaluation of adverse effects of chemotherapy regimens of 5-fluoropyrimidines derivatives and their association with DPYD polymorphisms in colorectal cancer patients

 

Polymorphism IVS14 + 1G > A

ADR

 

Heterozygous

Normal

Total

P-value

Diarrhea

Exist

1 (1.4%)

16 (21.9%)

17 (23.3%)

0.663

Absent

3 (4.1%)

53 (72.6%)

56 (76.7%)

Nausea

Exist

0

30 (41.1%)

30 (41.1%)

0.113

Absent

4 (5.5%)

39 (53.4%)

43 (58.9%)

Vomiting

Exist

1 (1.4%)

16 (21.9%)

17 (23.3%)

0.663

Absent

3 (4.1%)

53 (72.6%)

56 (76.7%)

Oral mucositis

Exist

2 (2.7%)

27 (37%)

29 (39.7%)

0.522

Absent

2 (2.7%)

42 (57.6%)

44 (60.3%)

Peripheral neuropathy

Exist

4 (5.5%)

64 (87.7%)

68 (93.2%)

0.748

Absent

0

5 (6.8%)

5 (6.8%)

Hair loss

Exist

4 (5.5%)

37 (50.7%)

41 (56.2%)

0.093

Absent

0

32 (43.8%)

32 (43.8%)