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Table 1 Effects of differentially expressed genes on disease and cell function after Prdx1 inhibition

From: Prdx1 promotes the loss of primary cilia in esophageal squamous cell carcinoma

Diseases or Functions Annotation

Activation z-score

p-Value

Differentially expressed genes (n)

Tumorigenesis of tissue

−0.137

4.02E-13

656

Proliferation of tumor cells

0.927

1.52E-10

56

Proliferation of cells

−0.89

5.22E-10

269

Migration of tumor cell lines

−0.848

1.62E-09

76

Cell proliferation of tumor cell lines

−0.281

7.1E-09

134

Microtubule dynamics

1.768

1.43E-08

106

Apoptosis of tumor cell lines

1.059

1.62E-08

108

Invasion of cells

−0.289

5.28E-08

82

Cell death of tumor cell lines

1.059

5.87E-08

127

Formation of cellular protrusions

2.545

0.00000043

82

Cell movement of carcinoma cell lines

−2.11

0.00000964

25

Migration of carcinoma cell lines

−2.082

0.0000125

22

Invasion of tumor cell lines

−0.362

0.000000636

64

Attachment of cells

2.187

0.000382

15

Engulfment of tumor cell lines

−1.75

0.000264

16

Gastrointestinal tract cancer

−0.926

0.000329

491

Extension of neurites

1.946

0.000335

18

Migration of pancreatic cancer cell lines

−1.912

0.000338

8

Development of kidney cell lines

−1.118

0.000369

7

Cell proliferation of kidney cell lines

−1.154

0.000426

18

Colony formation of lung cancer cell lines

−1.153

0.000448

8

Invasion of digestive organ tumor

−1

0.000512

8

Invasion of epithelial cell lines

−1.577

0.000598

7

Metastatic potential of tumor cell lines

−1.404

0.000738

6

Extension of cellular protrusions

1.257

0.00075

20

Apoptosis of colorectal cancer cell lines

1.064

0.000782

22

Degeneration of nervous system

−2.101

0.000892

26

Migration of prostate cancer cell lines

−1.087

0.000924

12

Degeneration of neurons

−1.153

0.00133

22

Neurodegeneration

−1.99

0.00136

27

  1. Z-score > 2 signifies that the function is significantly activated. Z-score < −2 signifies that the function is significantly inhibited. All diseases and functions are sorted using -Log (P-value), ranking from high to the bottom according to the value of -log (p-value)