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Table 3 Characteristics of 49 patients with resection

From: Neoadjuvant chemotherapy followed by curative-intent surgery for perihilar cholangiocarcinoma based on its anatomical resectability classification and lymph node status

FactorsR (n = 26)BR (n = 17)LA (n = 6)p value
Age (years)72 (44–87)70 (51–80)65 (53–84)0.478
Gender (male / female)14 / 129 / 84 / 20.830
Biliary drainage (%)24 (92.3%)11 (64.7%)5 (83.3%)0.073
Adjuvant therapy (%)6 (23.1%)15 (88.2%)6 (100%)< 0.001*
 Chemotherapy6154 
 Chemoradiotherapy002 
Portal vein embolization (%)2 (7.7%)4 (23.5%)1 (14.3%)0.344
Preoperative blood examination
 Neutrophil-to-lymphocyte ratio2.31 (0.97–8.15)2.43 (1.52–6.15)3.86 (0.99–6.46)0.276
 Prognostic nuritional index42.4 (33.9–55.6)43.8 (36.3–50.1)42.6 (32.7–46.8)0.707
 CEA (mg/dl)3.0 (0.5–30.8)3.7 (1.5–24.4)2.6 (2.2–5.4)0.644
 CA19–9 (U/ml)59.6 (12.6–11,659)69.7 (1–1158)196.6 (8.0–669.3)0.715
Histological differentiation   0.473
 G1/2 (%)24 (96.0%)15 (88.2%)6 (100%) 
  G3 (%)1 (4.0%)2 (11.8%)0 
Pathological finding
 pT4 (%)2 (7.7%)7 (41.2%)3 (50.0%)0.013*
  Lymph node metastasis (%)9 (34.6%)11 (64.7%)3 (50.0%)0.152
 Intrahepatic metastasis (%)1 (3.8%)2 (11.8%)00.457
Residual tumor
 R0 (%)16 (61.5%)12 (70.6%)4 (66.7%)0.828
 R1631 
 R2421 
  1. R: resectable, BR: borderline resectable, LA: locally advanced * R vs. BR, UR
  2. CEA carcinoembryonic antigen, CA19–9 carbohydrate antigen 19–9, R0 complete resection, R1: microscopic residual tumor resection, R2: macroscopic residual tumor resection or distant metastasis (intrahepatic metastasis)