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Table 3 Characteristics of 49 patients with resection

From: Neoadjuvant chemotherapy followed by curative-intent surgery for perihilar cholangiocarcinoma based on its anatomical resectability classification and lymph node status

Factors

R (n = 26)

BR (n = 17)

LA (n = 6)

p value

Age (years)

72 (44–87)

70 (51–80)

65 (53–84)

0.478

Gender (male / female)

14 / 12

9 / 8

4 / 2

0.830

Biliary drainage (%)

24 (92.3%)

11 (64.7%)

5 (83.3%)

0.073

Adjuvant therapy (%)

6 (23.1%)

15 (88.2%)

6 (100%)

< 0.001*

 Chemotherapy

6

15

4

 

 Chemoradiotherapy

0

0

2

 

Portal vein embolization (%)

2 (7.7%)

4 (23.5%)

1 (14.3%)

0.344

Preoperative blood examination

 Neutrophil-to-lymphocyte ratio

2.31 (0.97–8.15)

2.43 (1.52–6.15)

3.86 (0.99–6.46)

0.276

 Prognostic nuritional index

42.4 (33.9–55.6)

43.8 (36.3–50.1)

42.6 (32.7–46.8)

0.707

 CEA (mg/dl)

3.0 (0.5–30.8)

3.7 (1.5–24.4)

2.6 (2.2–5.4)

0.644

 CA19–9 (U/ml)

59.6 (12.6–11,659)

69.7 (1–1158)

196.6 (8.0–669.3)

0.715

Histological differentiation

   

0.473

 G1/2 (%)

24 (96.0%)

15 (88.2%)

6 (100%)

 

  G3 (%)

1 (4.0%)

2 (11.8%)

0

 

Pathological finding

 pT4 (%)

2 (7.7%)

7 (41.2%)

3 (50.0%)

0.013*

  Lymph node metastasis (%)

9 (34.6%)

11 (64.7%)

3 (50.0%)

0.152

 Intrahepatic metastasis (%)

1 (3.8%)

2 (11.8%)

0

0.457

Residual tumor

 R0 (%)

16 (61.5%)

12 (70.6%)

4 (66.7%)

0.828

 R1

6

3

1

 

 R2

4

2

1

 
  1. R: resectable, BR: borderline resectable, LA: locally advanced * R vs. BR, UR
  2. CEA carcinoembryonic antigen, CA19–9 carbohydrate antigen 19–9, R0 complete resection, R1: microscopic residual tumor resection, R2: macroscopic residual tumor resection or distant metastasis (intrahepatic metastasis)