Table 8 QoL assessement (EORTC QLQ C30 and EORTC QLQ BR 23) by site of metastases and time (Mean scores and standard errors)

Physical Functioning

59.8 (5.0)

77.9 (3.9)

74.3 (5.6)

73.1 (4.2)

68.6 (5.5)

73.4 (4.2)

67.9 (6.7)

67.9 (5.3)

60.0 (6.2)

71.1 (5.2)

0.5868

Role Functioning

55.9 (6.5)

74.8 (5.2)

62.0 (7.6)

65.1 (5.6)

65.0 (6.8)

67.8 (5.3)

67.1 (8.4)

62.6 (6.9)

61.7 (9.2)

63.9 (7.8)

0.9142

Emotional Functioning

58.1 (4.8)

61.6 (3.8)

70.2 (6.1)

65.7 (4.4)

68.9 (5.1)

72.2 (4.0)

66.9 (6.1)

67.9 (4.9)

63.8 (6.0)

75.2 (5.2)

0.6476

Cognitive Functioning

89.4 (3.2)

91.1 (2.5)

82.3 (4.8)

81.2 (3.6)

83.1 (4.9)

81.7 (3.9)

79.5 (5.7)

80.5 (4.5)

77.4 (5.4)

81.3 (4.7)

0.9127

Social Functioning

69.3 (6.3)

72.8 (5.0)

81.0 (6.9)

70.0 (5.0)

77.7 (6.4)

77.7 (5.1)

69.5 (7.7)

72.4 (6.4)

65.3 (5.5)

84.5 (4.7)

0.6739

Global health status/QoL

53.2 (5.0)

55.3 (3.9)

65.0 (5.7)

65.6 (4.0)

65.5 (4.8)

69.5 (3.8)

60.8 (6.6)

70.0 (5.5)

57.4 (5.3)

74.3 (4.8)

0.1450

Fatigue

43.9 (5.5)

32.2 (4.3)

40.9 (6.9)

37.8 (5.0)

45.1 (6.2)

36.1 (4.9)

37.7 (6.9)

35.4 (5.6)

41.5 (6.3)

36.7 (5.3)

0.5008

Nausea/Vomiting

7.6 (3.2)

8.1 (2.5)

3.1 (3.1)

8.7 (2.3)

13.6 (4.2)

5.6 (3.3)

7.7 (3.6)

6.7 (2.9)

15.8 (5.2)

4.8 (4.4)

0.2928

Pain

52.0 (6.4)

24.6 (5.0)

28.3 (6.7)

25.7 (4.9)

29.1 (5.7)

22.4 (4.5)

31.7 (7.0)

27.0 (5.6)

38.6 (6.7)

21.9 (5.5)

0.2660

Dyspnoea

22.3 (5.2)

14.4 (4.0)

24.7 (6.4)

22.5 (4.6)

25.0 (6.6)

25.8 (5.2)

44.4 (9.4)

30.1 (7.6)

38.4 (7.5)

26.1 (6.1)

0.3687

Insomnia

33.3 (6.1)

40.1 (4.8)

19.1 (7.1)

34.4 (5.0)

28.0 (6.9)

34.0 (5.4)

28.9 (7.4)

32.3 (6.1)

35.0 (7.1)

26.8 (6.1)

0.5571

Appetite loss

22.2 (6.2)

22.1 (4.9)

16.1 (7.0)

17.8 (5.1)

19.0 (6.0)

16.6 (4.7)

12.9 (5.3)

15.5 (4.4)

22.9 (5.4)

11.5 (4.8)

0.6599

Constipation

22.9 (5.6)

17.9 (4.5)

22.4 (7.6)

23.2 (5.6)

17.1 (6.4)

23.7 (5.0)

12.3 (7.0)

20.0 (5.6)

28.1 (7.3)

12.4 (6.4)

0.9843

Diarhoea

3.3 (3.6)

8.3 (2.8)

4.2 (5.5)

12.6 (4.1)

9.6 (4.1)

8.5 (3.2)

8.1 (5.5)

11.5 (4.4)

7.1 (3.5)

5.3 (2.9)

0.6297

Financial Problems

7.6 (4.9)

15.5 (3.8)

9.9 (6.5)

24.2 (4.7)

20.6 (6.6)

24.0 (5.2)

23.8 (7.1)

26.6 (5.6)

18.7 (5.4)

18.8 (4.5)

0.4584

Body image

81.8 (4.0)

84.1 (3.3)

80.4 (6.3)

72.1 (4.7)

83.7 (4.6)

81.8 (3.6)

74.5 (5.7)

82.0 (4.6)

68.1 (5.9)

78.1 (4.8)

0.7569

Sexual functioning

15.7 (4.8)

15.9 (4.0)

17.5 (5.2)

17.5 (3.9)

11.4 (6.1)

26.0 (4.9)

13.7 (6.2)

24.9 (5.2)

14.0 (6.2)

22.2 (5.4)

0.1794

Future perspective

33.2 (6.2)

35.5 (5.1)

42.6 (7.3)

36.3 (5.3)

47.2 (7.3)

48.1 (5.7)

45.8 (8.3)

38.7 (6.7)

37.1 (7.7)

66.8 (6.7)

0.5522

Systematic therapy

21.8 (3.1)

14.9 (2.5)

26.1 (4.9)

31.6 (3.6)

22.9 (3.3)

17.5 (2.6)

26.9 (4.4)

23.2 (3.5)

26.0 (3.6)

20.3 (3.0)

0.5631

Breast symptoms

22.4 (3.8)

18.8 (3.2)

15.4 (3.8)

13.9 (2.8)

13.0 (3.0)

11.2 (2.3)

10.1 (4.3)

12.4 (3.4)

13.9 (3.9)

5.3 (3.4)

0.4986

Arm symptoms

21.4 (3.4)

12.6 (2.7)

24.4 (5.2)

19.4 (3.9)

22.3 (4.6)

17.4 (3.6)

29.4 (5.6)

20.7 (4.4)

21.0 (5.1)

14.5 (4.2)

0.2467

Hair loss

7.2 (2.7)

1.2 (2.2)

29.7 (8.5)

30.0 (6.3)

16.2 (5.3)

2.6 (3.9)

23.8 (5.9)

7.1 (4.6)

15.0 (7.9)

9.7 (6.5)

0.1468