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Table 7 Intra-laboratory reproducibility and inter-laboratory agreement of individual genotype findings in ThinPrep screening samples

From: Clinical validation of full genotyping CLART® HPV4S assay on SurePath and ThinPrep collected screening samples according to the international guidelines for human papillomavirus test requirements for cervical screening

Assessment and Hr-HPV type No. of genotype findings per run or laboratory No. negative for both runs Kappa Value 95% Confidence Interval
Combined results First run Second run Lower Upper
Intra-laboratory reproducibility
 16 16 26 17 464 0.73 0.58 0.88
 18 4 6 6 483 0.66 0.35 0.97
 31 9 11 9 480 0.90 0.76 1.00
 33 3 3 3 488 1.00 1.00 1.00
 35 3 3 5 486 0.75 0.41 1.00
 39 1 7 1 484 0.25 −0.15 0.64
 45 6 8 7 482 0.80 0.57 1.00
 51 2 8 2 483 0.40 0.01 0.78
 52 8 11 8 480 0.84 0.66 1.00
 56 0 8 0 483 0.00 0.00 0.00
 58 4 8 5 482 0.61 0.30 0.92
 59 0 1 0 490 0.00 0.00 0.00
 66 0 0 0 491 0.00 0.00 0.00
 68 4 7 4 484 0.72 0.43 1.00
Inter-laboratory agreement
 16 20 26 25 464 0.77 0.64 0.90
 18 5 5 6 489 0.91 0.73 1.00
 31 9 11 11 482 0.81 0.64 0.99
 33 2 3 2 492 0.80 0.41 1.00
 35 3 3 4 491 0.86 0.58 1.00
 39 5 7 5 488 0.83 0.60 1.00
 45 5 8 7 485 0.66 0.38 0.94
 51 4 8 4 487 0.66 0.35 0.97
 52 10 11 11 483 0.91 0.78 1.00
 56 4 8 5 486 0.61 0.30 0.92
 58 6 8 8 485 0.75 0.51 0.99
 59 2 2 4 491 0.67 0.23 1.00
 66 0 0 0 495 0.00 0.00 0.00
 68 6 6 7 488 0.92 0.77 1.00