N = 598 | OS | PFS | ||||||
---|---|---|---|---|---|---|---|---|
p value | HR | 95%CI | p value | HR | 95%CI | |||
Myelosupression | ||||||||
Degree I | 103 | 0.001 | 3.117 | 1.809–4.371 | 0.148 | 1.47 | 0.872–2.48 | |
Degree II | 137 | 0.075 | 1.371 | 0.911–2.943 | 0.598 | 1.157 | 0.372–1.993 | |
Degree III | 63 | 0.102 | 1.591 | 0.911–2.776 | 0.680 | 1.119 | 0.656–1.909 | |
Degree IV | 15 | 0.998 | 1.001 | 0.552–1.814 | 0.600 | 0.860 | 0.489–1.512 | |
Diarrhea | ||||||||
Grade1 | 519 | |||||||
Grade2 | 52 | 0.196 | 0.757 | 0.496–1.155 | 0.227 | 0.787 | 0.533–1.161 | |
Grade3 | 27 | 0.045 | 0.580 | 0.40–0.989 | 0.313 | 0.785 | 0.490–1.256 | |
Vomiting | ||||||||
Grade1 | 136 | |||||||
Grade 2 | 443 | 0.189 | 0.702 | 0.414–1.190 | 0.738 | 0.917 | 0.553–1.521 | |
Grade 3 | 19 | 0.213 | 0.727 | 0.440–1.201 | 0.252 | 0.752 | 0.462–1.225 |