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Table 1 Dose and fractionations by site with [secondary options in square brackets]

From: Stereotactic ablative radiotherapy for the comprehensive treatment of 1–3 Oligometastatic tumors (SABR-COMET-3): study protocol for a randomized phase III trial

Tumor Location

Description

Total Dose (Gy)

Number of fractions

Dose per fraction (Gy)

Frequency

Lung

Tumors 5 cm or less surrounded by lung parenchyma

48 [54]

4 [3]

12 [18]

Daily, or Every second day

Within 2 cm of mediastinum or brachial plexus

60

8

7.5

Daily

Bone

Any bone

35 Gy [24]

5 [2]

7 [12]

Daily

Brain

Stereotactic lesions (no whole brain RT)

< 2 cm

24

1

24

Once

2–3 cm

18

1

18

Once

3–4 cm

15

1

15

Once

If whole brain treated, then simultaneous boost to each lesion

35Gy to metastases 20 Gy whole brain (Opt)

5

7 Gy to PTV

Daily

4 Gy WBRT

Liver

54 Gy

3

18

Every second day

Adrenal

40 Gy

5

8

daily

Lymph Node/Soft Tissue

40 Gy

5

8

daily

  1. RT – radiotherapy; WBRT – whole brain radiotherapy