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Table 4 Hematopoietic reconstitution - multivariate analysis

From: Low-dose peripheral blood stem cell graft after high-dose chemotherapy - an evaluation of hematopoietic reconstitution

Parameter

Leukocyte reconstitution (≥1.0 × 109/L)

Aplasia

Platelet reconstitution (≥20 × 109/L)

Platelet reconstitution (≥50 × 109/L)

n analyzed

130

103

131

76

 

HR (CI95)

P value

HR (CI95)

P value

HR (CI95)

P value

HR (CI95)

P value

Age at ABSCT (≤60 vs. > 60 years)

1.038 (0.730–1.476)

0.837

1.101 (0.725–1.669)

0.652

1.086 (0.762–1.547)

0.649

0.841 (0.529–1.336)

0.463

Remission pre ABSCT (CR/nCR/VGPR vs. PR/MR/SD/PD)

0.989 (0.681–1.436)

0.952

1.129 (0.735–1.734)

0.581

1.098 (0.755–1.598)

0.625

1.060 (0.650–1.729)

0.815

G-CSF support (no vs. yes)

16.742 (8.514–32.923)

< 0.001

9.634 (5.425–17.107)

< 0.001

1.365 (0.951–1.958)

0.091

1.084 (0.655–1.794)

0.753

CD34+ cells/kg bw transplanted (3–4 vs. 2–2.5 × 106)

0.607 (0.416–0.885)

0.010

0.573 (0.375–0.875)

0.010

0.438 (0.299–0.642)

< 0.001

0.442 (0.258–0.755)

0.003

  1. ASCT autologous blood stem cell transplantation; CI confidence interval; CR complete remission; HR hazard ratio; G-CSF granulocyte-colony stimulating factor; MR minimal response; nCR near complete remission; PD progressive disease; PR partial remission; SD stable disease; VGPR very good partial remission; vs., versus