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Table 3 Hematopoietic reconstitution after high-dose chemotherapy/ASCT by number of transplanted CD34+ cells

From: Low-dose peripheral blood stem cell graft after high-dose chemotherapy - an evaluation of hematopoietic reconstitution

ParameterOverall cohortGroup 1 (3–4 × 106 CD34+ cells /kg bw)Group 2 (2–2.5 × 106 CD34+ cells /kg bw)P value Group 1 vs. 2Group 3 (< 2 × 106 CD34+ cells /kg bw)
ASCTs analyzed, n1488653 9
G-CSF support, n (%)   0.271 
 Yes62 (42)34 (40)26 (49)2 (22)
 No86 (58)52 (60)27 (51)7 (78)
Leukocyte reconstitution   0.393 
 n available14482539
 Days to L ≥ 1.0 × 109/L12 (9–24)12 (9–23)12 (10–24)12 (9–16)
Neutrophil reconstitution   / 
 n available4217232
 Days to N ≥ 0.5 × 109/L14 (9–19)14 (9–19)13 (10–18)13 (11–14)
Aplasia   0.513 
 n available11662468
 Days in aplasia9 (4–20)9 (4–19)8 (5–20)9 (5–13)
Platelet reconstitution   < 0.001 
 n available14485518
 Days to platelets ≥20 × 109/L12 (9–21)11 (9–16)13 (10–21)13 (9–19)
 n available8155230.0013
 Days to platelets ≥50 × 109/L14 (10–22)14 (10–18)14 (13–22)15 (13–18)
  1. If not otherwise indicated, the data are presented as the median (range)
  2. ASCT autologous blood stem cell transplantation; G-CSF granulocyte-colony stimulating factor; L leukocytes, NA not available; N neutrophils; vs., versus