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Table 3 Hematopoietic reconstitution after high-dose chemotherapy/ASCT by number of transplanted CD34+ cells

From: Low-dose peripheral blood stem cell graft after high-dose chemotherapy - an evaluation of hematopoietic reconstitution

Parameter

Overall cohort

Group 1 (3–4 × 106 CD34+ cells /kg bw)

Group 2 (2–2.5 × 106 CD34+ cells /kg bw)

P value Group 1 vs. 2

Group 3 (< 2 × 106 CD34+ cells /kg bw)

ASCTs analyzed, n

148

86

53

 

9

G-CSF support, n (%)

   

0.271

 

 Yes

62 (42)

34 (40)

26 (49)

2 (22)

 No

86 (58)

52 (60)

27 (51)

7 (78)

Leukocyte reconstitution

   

0.393

 

 n available

144

82

53

9

 Days to L ≥ 1.0 × 109/L

12 (9–24)

12 (9–23)

12 (10–24)

12 (9–16)

Neutrophil reconstitution

   

/

 

 n available

42

17

23

2

 Days to N ≥ 0.5 × 109/L

14 (9–19)

14 (9–19)

13 (10–18)

13 (11–14)

Aplasia

   

0.513

 

 n available

116

62

46

8

 Days in aplasia

9 (4–20)

9 (4–19)

8 (5–20)

9 (5–13)

Platelet reconstitution

   

< 0.001

 

 n available

144

85

51

8

 Days to platelets ≥20 × 109/L

12 (9–21)

11 (9–16)

13 (10–21)

13 (9–19)

 n available

81

55

23

0.001

3

 Days to platelets ≥50 × 109/L

14 (10–22)

14 (10–18)

14 (13–22)

15 (13–18)

  1. If not otherwise indicated, the data are presented as the median (range)
  2. ASCT autologous blood stem cell transplantation; G-CSF granulocyte-colony stimulating factor; L leukocytes, NA not available; N neutrophils; vs., versus