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Table 3 Results of subgroup and meta-regression analyses in the prognostic meta-analysis

From: Biomarker roles identification of miR-106 family for predicting the risk and poor survival of colorectal cancer

Outcome

Subgroup

Studies

HR (95%CI)

P-value

Heterogeneity (I2)

Pheterogeneity

Meta-regression (P-value)

DFS

miRNA classification

     

P = 0.237

 

miR-106a

6

1.44(0.88–2.35)

P = 0.151

79.9%

P < 0.001

 
 

miR-106b

5

2.19(1.61–3.00)

P < 0.001

0

P = 0.938

 
 

Ethnicity

     

P = 0.322

 

Asian

7

2.02(1.60–2.57)

P = 0.569

81.7%

P = 0.001

 
 

Non-Asian

4

1.24(0.59–2.60)

P < 0.001

0

P = 0.507

 

OS

miRNA classification

     

P = 0.584

 

miR-106a

9

1.45(1.16–1.80)

P = 0.001

48.6%

P = 0.049

 
 

miR-106b

2

1.57 (0.35–7.08)

P = 0.555

80.6%

P = 0.023

 
 

Ethnicity

     

P = 0.648

 

Asian

5

1.50(1.00–2.24)

P = 0.050

79.1%

P = 0.001

 
 

Non-Asian

6

1.33(0.94–1.88)

P = 0.107

56.8%

P = 0.041

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