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Table 3 Age-dependent incidence rate ratios of specific cancer types in the FCCTX cohort without the 37 families that fulfilled the criteria for genetic testing for hereditary breast and ovarian cancer or hereditary gastric cancer conpared to the age and sex-matched population-based cohort

From: Broadening risk profile in familial colorectal cancer type X; increased risk for five cancer types in the national Danish cohort

  

FCCTX subset vs. Population-based cohort

Cancer

Age groups

IRR

95% CI lower

95% CI Upper

P values

Breast cancer (n = 36)

0–29

0.00

0.00

23.91

1.0000

30–49

0.19

0.02

0.67

0.0002*

50–69

0.80

0.46

1.26

0.2639

70+

0.56

0.19

1.27

0.1104

Urothelial cancer (n = 33)

0–29

10.10

0.06

73.70

0.0947

30–49

0.51

0.00

3.65

1.0000

50–69

0.65

0.25

1.36

0.2011

70+

1.53

0.83

2.59

0.0568

Lung cancer (n = 25)

0–29

0.00

0.00

82.68

1.0000

30–49

0.97

0.17

2.97

1.0000

50–69

0.35

0.15

0.67

< 0.0001*

70+

0.32

0.11

0.74

0.0002*

Pancreatic cancer (n = 13)

0–29

0.00

0.00

351.13

1.0000

30–49

0.00

0.00

5.78

1.0000

50–69

0.75

0.17

2.08

0.6967

70+

1.27

0.42

2.89

0.4249

Gastric cancer (n = 12)

0–29

0.00

0.00

137.04

1.0000

30–49

2.94

0.36

10.51

0.0840

50–69

0.38

0.02

1.73

0.2642

70+

1.27

0.39

3.04

0.5161

Eye tumours (n = 4)

0–29

0.00

0.00

40.98

1.0000

30–49

0.00

0.00

18.10

1.0000

50–69

6.19

1.11

19.07

0.0044*

70+

0.00

0.00

15.20

1.0000

  1. *Significant p values following Bonferoni correction