| Assessment | ⋅ No standard diagnostic tool | ⋅ Standard diagnostic tool |
| ⋅ No systematic CRF assessment | ⋅ Systematic CRF assessment |
| ⋅ Patient orientation |
| Reporting | ⋅ CRF has multiple causes | ⋅ Encouraging patients to report CRF symptoms |
| ⋅ CRF differs in its clinical expression in the individual patients |
| ⋅ Patients rarely address symptoms of fatigue on their own accord |
| Information | ⋅ No specific systematic information of patients about CRF | ⋅ Information about CRF early after diagnoses |
| ⋅ Online information tool |
| Treatability | ⋅ Not treatable with a single intervention | ⋅ Interdisciplinary collaboration |
| ⋅ No treatment guidelines in the hospital | ⋅ Integrative treatment program |
| ⋅ Monitoring |
| ⋅ Working towards self-efficacy of the patients |
| Attitude | ⋅ Feelings of helplessness | ⋅ Patient-orientation |
| ⋅ Experiencing a life-threatening disease | ⋅ Individualized approach |
| ⋅ Self-Care options |
| ⋅ Self-management |
| Infrastructure | ⋅ Hospitals are short of infrastructure | ⋅ Drop-in-center (coordination, monitoring) |
| Time-management | ⋅ Doctors and patients are short of time | ⋅ Prioritization of treatments |
| ⋅ Overload of consultations and therapies | ⋅ Focus on self-care |
| ⋅ Coordination of work and treatment | ⋅ Geographically reachable treatment options |
| Costs and affordability | ⋅ Hospitals are short of manpower | ⋅ Coverage by public health insurance |
| ⋅ No coverage by public health insurance | ⋅ Social welfare funds |
| Integrative approach | ⋅ Lack of interdisciplinary collaboration | ⋅ Evidence-based integrative medicine approach |
| ⋅ Lack of coordinated integrative programs | ⋅ Integrative treatment program |
