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Table 3 Cox Proportional Hazard Regression analysis for OS

From: Correlation between initial tumour volume and treatment duration on Dabrafenib: observation study of subjects with BRAF mutant melanoma on the BRF112680 trial

Variable

Univariate analysis

Multivariate analysis

HR (95% CI)

P-value

HR (95% CI)

P-value

Age/years

0.998 (0.917–1.087)

= 0.971

1.144 (0.681–1.922)

= 0.610

ECOG

0.707 (0.042–11.79)

= 0.809

  

TV (cc)

1.005 (0.983–1.029)

= 0.639

2.814 (1.059–6.189)

= 0.047

LDH

0.909 (0.631–1.311)

= 0.610

  

RECIST response (PD)

4.243 (0.255–17.15)

= 0.314

3.242 (1.005–22.38)

= 0.044

  1. CI confidence interval, ECOG European Cooperative Oncology Group, HR hazard ratio, LDH lactate dehydrogenase, PR partial remission, PD progressive disease, RECIST response criteria in solid tumors, SD standard deviation, TV tumor volume
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