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Fig. 5 | BMC Cancer

Fig. 5

From: NAD(P)-dependent steroid dehydrogenase-like is involved in breast cancer cell growth and metastasis

Fig. 5

NSDHL knockdown suppressed tumor growth and lung metastasis of MDA-MB-231 xenograft mice. a, b Data of relative NSDHL mRNA level analyzed by real-time RT-PCR and representative western blot images of NSDHL in MDA-MB-231 cells transduced with NSDHL shRNA or control shRNA lentivirus; c Data of tumor volume measured weekly in NSDHL shRNA or control shRNA mice; d Gross images and wet weight of tumors removed from NSDHL shRNA or control shRNA mice at 44 days post-injection; e Representative NSDHL immunohistochemistry image and scores analyzed from NSDHL shRNA or control shRNA tumor tissues; f Gross and H&E images of lungs and data of metastatic foci analyzed from NSDHL shRNA or control shRNA lung tissues. In vitro data represent the means ± standard deviations of three independent experiments. Animal data represent the means ± standard deviations of five mice per group. *p < 0.05, **p < 0.01

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