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Table 2 SNPs correlate with severity of TIPN† (grade 0–1 vs. grade 2–3) in all patients and in breast cancer patients (subset analysis), and SNPs correlate with TIPNa (grade 0–1 vs. grade 2–3) at 1 year after completion of taxane treatment in all patients

From: Taxane-induced sensory peripheral neuropathy is associated with an SCN9A single nucleotide polymorphism in Japanese patients

GeneSNPOdds ratioOdds ratio (95% C.I. b)P-value
SCN9Ars76079671.7490.889–3.4410.1054
rs129943380.9520.492–1.8410.8836
rs130176373.4631.456–8.2370.0050
SCN10Ars126329421.0240.498–8.2370.9491
rs67959700.9490.450–1.9980.8894
A subset analysis in Breast only
SCN9Ars76079671.8220.864–3.8420.1151
rs129943380.9130.442–1.8880.8061
rs130176375.0531.743–14.6410.0029
SCN10Ars126329421.2620.569–2.8020.567
rs67959701.1350.515–2.5010.7537
Analysis at 1 year after completion of taxane treatment in all patients
SCN9Ars76079670.7350.313–1.7280.4805
rs129943380.9520.418–2.1670.9069
rs130176373.9061.084–14.0750.03719
SCN10Ars126329420.5600.219–1.4300.225
rs67959701.8340.697–4.8260.2192
  1. aTIPN taxane-induced peripheral neuropathy, bC.I. confidence interval