Table 6 The distribution of the haplotypes constructed by SNPs in ERAP1 gene
Haplotypes | Control (Freq) | CIN (Freq) | Cervical cancer (Freq) | Cervical cancer vs Control | Â | CIN vs Control | Â | Cervical cancer vs CIN | |
|---|---|---|---|---|---|---|---|---|---|
P-value | OR[95%CI] | P-value | OR[95%CI] | P-value | OR[95%CI] | ||||
G-C-C-C-C | 646.12 (25.6%) | 299.22 (26.9%) | 556.04 (25.9%) | 0.041 | 1.151 [1.006–1.316] | 0.122 | 1.137 [0.966–1.338] | 0.890 | 1.012 [0.855–1.197] |
G-T-T-G-C | 76.43 (3.0%) | 37.05 (3.3%) | 64.76 (3.0%) | 0.612 | 1.091 [0.779–1.528] | 0.486 | 1.153 [0.773–1.719] | 0.794 | 0.947 [0.627–1.428] |
C-T-T-G-C | 1101.70 (43.7%) | 444.48 (40.0%) | 759.76 (35.4%) | 0.001 | 0.804 [0.711–0.910] | 0.260 | 0.918 [0.791–1.065] | 0.096 | 0.876 [0.750–1.024] |
G-C-T-C-C | 196.08 (7.8%) | 72.59 (6.5%) | 176.09 (8.2%) | 0.150 | 1.169 [0.945–1.447] | 0.315 | 0.866 [0.655–1.146] | 0.039 | 1.350 [1.015–1.795] |
G-C-T-C-T | 336.22 (13.3%) | 142.58 (12.8%) | 278.80(13.0%) | 0.402 | 1.076 [0.906–1.278] | 0.970 | 1.004 [0.813–1.241] | 0.533 | 1.072 [0.862–1.334] |