Table 3 The allelic and genotypic distribution among control, CIN and cervical cancer groups of SNPs in ERAP2 gene
SNPs | Control (Freq) | CIN (Freq) | Cervical cancer (Freq) | Cervical cancer vs Control | Â | CIN vs Control | Â | Cervical cancer vs CIN | |
|---|---|---|---|---|---|---|---|---|---|
P-value | OR[95%CI] | P-value | OR[95%CI] | P-value | OR[95%CI] | ||||
rs2549782 | |||||||||
 T | 1418 (56.2%) | 628 (56.5%) | 1146 (53.5%) | 0.062 | 1.117 [0.995–1.253] | 0.869 | 0.988 [0.857–1.139] | 0.100 | 1.130 [0.977–1.307] |
 G | 1106 (43.8%) | 484 (43.5%) | 998 (46.5%) | ||||||
 T/T | 395 (31.3%) | 173 (31.1%) | 291 (27.1%) | 0.089 |  | 0.906 |  | 0.214 |  |
 G/T | 628 (49.8%) | 282 (50.7%) | 564 (52.6%) |  |  |  | |||
 G/G | 239 (18.9%) | 101 (18.2%) | 217 (20.2%) |  |  |  | |||
rs2548538 | |||||||||
 T | 1461 (57.9%) | 638 (57.4%) | 1185 (55.3%) | 0.073 | 1.112 [0.990–1.249] | 0.774 | 1.021 [0.885–1.178] | 0.252 | 1.089 [0.941–1.261] |
 A | 1063 (42.1%) | 474 (42.6%) | 959 (44.7%) | ||||||
 T/T | 439 (34.8%) | 189 (34.0%) | 337 (31.4%) | 0.197 |  | 0.948 |  | 0.524 |  |
 A/T | 583 (46.2%) | 260 (46.8%) | 511 (47.7%) |  |  |  | |||
 A/A | 240 (19.0%) | 107 (19.2%) | 224 (20.9%) |  |  |  | |||
rs2248374 | |||||||||
 G | 1396 (55.3%) | 625 (56.2%) | 1109 (51.7%) | 0.014 | 1.155 [1.029–1.296] | 0.616 | 0.964 [0.837–1.116] | 0.015 | 1.198 [1.035–1.386] |
 A | 1128 (44.7%) | 487 (43.8%) | 1035 (48.3%) | ||||||
 G/G | 382 (30.3%) | 169 (30.4%) | 269 (25.1%) | 0.020 |  | 0.690 |  | 0.041 |  |
 A/G | 632 (50.0%) | 287 (51.6%) | 571 (53.3%) |  |  |  | |||
 A/A | 248 (19.7%) | 100 (18.0%) | 232 (21.6%) |  |  |  | |||
rs2287988 | |||||||||
 A | 1407 (55.7%) | 623 (56.0%) | 1104 (51.5%) | 0.004 | 1.187 [1.057–1.332] | 0.875 | 0.989 [0.858–1.140] | 0.014 | 1.200 [1.038–1.388] |
 G | 1117 (44.3%) | 489 (44.0%) | 1040 (48.5%) | ||||||
 A/A | 387 (30.7%) | 167 (30.0%) | 267 (24.9%) | 0.007 |  | 0.743 |  | 0.039 |  |
 A/G | 633 (50.1%) | 289 (52.0%) | 570 (53.2%) |  |  |  | |||
G/G | 242 (19.2%) | 100 (18.0%) | 235 (21.9%) | Â | Â | Â | |||
rs1056983 | |||||||||
 T | 1462 (57.9%) | 647 (58.2%) | 1225 (57.1%) | 0.587 | 1.033 [0.919–1.160] | 0.884 | 0.989 [0.858–1.141] | 0.567 | 1.044 [0.901–1.209] |
 C | 1062 (42.1%) | 465 (41.8%) | 919 (42.9%) |  |  |  |  |  |  |
 T/T | 439 (34.8%) | 195 (35.1%) | 360 (33.6%) | 0.830 |  | 0.990 |  | 0.831 |  |
 C/T | 584 (46.3%) | 257 (46.2%) | 505 (47.1%) |  |  |  |  |  |  |
 C/C | 239 (18.9%) | 104 (18.7%) | 207 (19.3%) |  |  |  |  |  |  |