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Fig. 2 | BMC Cancer

Fig. 2

From: Sensitive detection methods are key to identify secondary EGFR c.2369C>T p.(Thr790Met) in non-small cell lung cancer tissue samples

Fig. 2

Percentage of analyzable tests with correct outcome over time for the 11 most frequently used c.2369C>T p.(Thr790Met) detection methods. Correct results are calculated in relation to the total number of analyzable tests (total tests minus technical failures). Analysis methods are represented as reported by the participants in the electronic datasheets. The category ‘next-generation sequencing’ includes both commercial and in-house panels. Non-commercial methods include in-house sequencing methods that are non-NGS based. The detailed percentage of correct results, false-negatives, wrong mutations and technical failures for these 11 methods is given in Supplemental Table 4. Abbreviations: ARMS, Amplification Refractory Mutation System; CAST, Competitive allele-specific TaqMan; EGFR, epidermal growth factor receptor; LNA, locked nucleic acid; PCR, polymerase chain reaction; PNA, peptide nucleic acid

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