Table 1 The enriched pathways by differentially expressed miRNAs
miRNA | ID | Pathway | P value | Count |
|---|---|---|---|---|
hsa-miR-9-5p | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 4.84E-05 | 4 |
hsa04926 | Relaxin signaling pathway | 2.51E-03 | 3 | |
hsa04218 | Cellular senescence | 4.51E-03 | 3 | |
hsa04115 | p53 signaling pathway | 9.18E-03 | 2 | |
hsa04520 | Adherens junction | 1.03E-02 | 2 | |
hsa04350 | TGF-beta signaling pathway | 1.38E-02 | 2 | |
hsa04974 | Protein digestion and absorption | 1.57E-02 | 2 | |
hsa05146 | Amoebiasis | 1.77E-02 | 2 | |
hsa05142 | Chagas disease (American trypanosomiasis) | 1.99E-02 | 2 | |
hsa-miR-31-3p | hsa04520 | Adherens junction | 1.90E-03 | 2 |
hsa04360 | Axon guidance | 1.08E-02 | 2 | |
hsa05165 | Human papillomavirus infection | 3.37E-02 | 2 | |
hsa04151 | PI3K-Akt signaling pathway | 4.04E-02 | 2 | |
hsa-miR-218-5p | hsa04974 | Protein digestion and absorption | 3.14E-05 | 5 |
hsa04520 | Adherens junction | 2.12E-04 | 4 | |
hsa04964 | Proximal tubule bicarbonate reclamation | 4.06E-03 | 2 | |
hsa04360 | Axon guidance | 5.77E-03 | 4 | |
hsa-miR-196a-5p | hsa04926 | Relaxin signaling pathway | 1.04E-03 | 3 |
hsa05202 | Transcriptional misregulation in cancer | 2.90E-03 | 3 | |
hsa05215 | Prostate cancer | 1.03E-02 | 2 | |
hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.07E-02 | 2 | |
hsa04916 | Melanogenesis | 1.11E-02 | 2 | |
hsa04022 | cGMP-PKG signaling pathway | 2.75E-02 | 2 | |
hsa04020 | Calcium signaling pathway | 3.37E-02 | 2 | |
hsa-miR-140-3p | hsa04360 | Axon guidance | 3.90E-03 | 3 |
hsa-miR-130a-5p | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 5.11E-04 | 4 |
hsa04520 | Adherens junction | 6.35E-04 | 4 | |
hsa05202 | Transcriptional misregulation in cancer | 3.41E-03 | 5 | |
hsa00910 | Nitrogen metabolism | 3.86E-03 | 2 | |
hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 9.62E-03 | 2 | |
hsa04666 | Fc gamma R-mediated phagocytosis | 1.37E-02 | 3 | |
hsa-miR-130a-3p | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.47E-03 | 4 |
hsa04911 | Insulin secretion | 3.14E-03 | 3 | |
hsa04015 | Rap1 signaling pathway | 5.38E-03 | 4 | |
hsa04960 | Aldosterone-regulated sodium reabsorption | 7.33E-03 | 2 | |
hsa04926 | Relaxin signaling pathway | 1.02E-02 | 3 | |
hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 1.16E-02 | 2 | |
hsa-miR-1246 | hsa04925 | Aldosterone synthesis and secretion | 8.59E-04 | 3 |
hsa04022 | cGMP-PKG signaling pathway | 3.92E-03 | 3 | |
hsa04927 | Cortisol synthesis and secretion | 6.97E-03 | 2 | |
hsa04918 | Thyroid hormone synthesis | 9.52E-03 | 2 | |
hsa04911 | Insulin secretion | 1.24E-02 | 2 | |
hsa04922 | Glucagon signaling pathway | 1.79E-02 | 2 | |
hsa04928 | Parathyroid hormone synthesis, secretion and action | 1.89E-02 | 2 | |
hsa04725 | Cholinergic synapse | 2.09E-02 | 2 | |
hsa04724 | Glutamatergic synapse | 2.17E-02 | 2 | |
hsa04926 | Relaxin signaling pathway | 2.77E-02 | 2 | |
hsa04728 | Dopaminergic synapse | 2.81E-02 | 2 | |
hsa04915 | Estrogen signaling pathway | 3.05E-02 | 2 | |
hsa04151 | PI3K-Akt signaling pathway | 3.17E-02 | 3 | |
hsa04261 | Adrenergic signaling in cardiomyocytes | 3.34E-02 | 2 | |
hsa04310 | Wnt signaling pathway | 3.43E-02 | 2 | |
hsa04934 | Cushing’s syndrome | 3.78E-02 | 2 | |
hsa-miR-1 | hsa05030 | Cocaine addiction | 2.45E-04 | 3 |
hsa04668 | TNF signaling pathway | 2.47E-03 | 3 | |
hsa05034 | Alcoholism | 1.03E-02 | 3 | |
hsa05031 | Amphetamine addiction | 1.29E-02 | 2 | |
hsa04657 | IL-17 signaling pathway | 2.32E-02 | 2 | |
hsa05215 | Prostate cancer | 2.51E-02 | 2 | |
hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.61E-02 | 2 | |
hsa04922 | Glucagon signaling pathway | 2.81E-02 | 2 | |
hsa04060 | Cytokine-cytokine receptor interaction | 3.02E-02 | 3 | |
hsa04152 | AMPK signaling pathway | 3.78E-02 | 2 | |
hsa04926 | Relaxin signaling pathway | 4.31E-02 | 2 | |
hsa04550 | Signaling pathways regulating pluripotency of stem cells | 4.86E-02 | 2 | |
hsa05418 | Fluid shear stress and atherosclerosis | 4.86E-02 | 2 |