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Table 1 Characteristics of included studies

From: Fertility sparing surgery vs radical surgery for epithelial ovarian cancer: a meta-analysis of overall survival and disease-free survival

Author

Year

Sample size

FSS

RS

Age group (yr)

Histology

Adjuvant chemo/radio therapy

Stage

Grade

Follow-up (yr)

  

FSS

RS

  

FSS

RS

FSS

RS

FSS

RS

FSS

RS

FSS

RS

 

Crafton et al

2020

1262

3823

Unilateral salpingo-oophorectomy and uterine preservation

Bilateral salpingo-oophorectomy or hysterectomy

Range: 15–44

Mucinous: 461

Endometroid: 418

Serous: 309

Clear cell: 368

Mucinous: 682

Endometroid: 1308

Serous: 1465

Clear cell: 368

Y:651

N: 611

Y:2569

N: 1254

IA/B: 590

IC: 321

II-IV: 351

IA/B: 1242

IC: 792

II-IV: 1789

1or2:956

3:306

1or2:2339

3:1484

4.61

Jiang et al

2017

52

56

Ipsilateral adnexectomy and biopsy or wedge excision of contralateral ovary

Hysterectomy and bilateral adnexectomy

251

351

Mucinous: 38

Endometroid: 1

Serous: 1

Clear cell: 2

Mucinous: 14

Endometroid: 16

Serous: 8

Clear cell: 18

Y:33

N:19

Y:50

N:6

IA/B: 19

IC1: 24

IC2/3:9

IA/B: 17

IC1: 31

IC2/3:8

1:45

2:4

3:1

1:27

2:8

3:3

6.91

Frusico et al

2016

242

789

Cystectomy or unilateral adnexectomy and complete peritoneal staging

Hysterectomy, bilateral salpingo-oophorectomy

31.32

53.12

Mucinous: 101

Endometroid: 55

Serous: 62

Clear cell: 17

Others:7

Mucinous: 152

Endometroid: 203

Serous: 237

Clear cell: 134

Others:56

Y:103

N:139

Y:494

N:295

IA: 129

IB: 2

IC1: 57

IC2/3:46

IA: 337

IB: 63

IC1: 136

IC2/3:223

1:145

2:69

3:27

1:225

2:225

3:320

11.91

Lee et al

2015

35

55

Unilateral salpingo-oophorectomy with surgical exploration. Surgical staging was optional

Patients other than those undergoing FS surgery

28.62

50.32

Mucinous:35

Mucinous:55

Y:14

N:21

Y:26

N:29

IA: 21

IB: 0

IC: 13

II: 1

IA: 34

IB: 1

IC: 17

II: 3

1:27

2:5

3:1

NK:2

1:34

2:15

3:2

NK:4

8.61

Ditto et al

2015

70

237

Preservation of the uterus, of at least one tube and the contralateral ovary

Radical comprehensive staging

301

511

Mucinous: 36

Endometroid: 8

Serous: 18

Others: 8

Mucinous: 2

Endometroid: 71

Serous: 83

Others: 48

Y:26

N:44

Y:169

N:68

IA: 46

IB: 2

IC: 15

II-III: 6

IA: 95

IB: 21

IC: 45

II-III: 76

1:36

2:24

3:9

1:64

2:80

3:85

FSS:6.41

RS:6.81

Kajiyama et al

2011

74

498

Conservation of the uterus and contralateral ovary and fallopian tube with at least a full peritoneal staging

Hysterectomy, and bilateral salpingo-oophorectomy with peritoneal staging

≤40

< 40 and > 40 age groups

Mucinous: 43

Endometroid: 14

Serous: 4

Clear cell: 13

Others:0

Mucinous: 107

Endometroid: 114

Serous: 60

Clear cell: 199

Others: 18

Y:54

N:20

Y:392

N:106

IA: 36

IB: 1

IC1: 21

IC2/3:16

IA: 155

IB: 6

IC1: 145

IC2/3:192

1or2:57

3:4

1or2:266

3:33

FSS:5.21

RS:5.51

Wright et al

2009

432

754

Unilateral oophorectomy

Bilateral oophorectomy

< 25:666

25–35: 181

36–50:185

< 25:64

25–35: 68

36–50:682

Mucinous: 211

Endometroid: 90

Serous: 98

Clear cell: 33

Mucinous: 188

Endometroid: 285

Serous: 160

Clear cell: 121

Y: 426

N:3

NK:3

Y: 720

N:22

NK:12

1A:370

1C:62

1A:551

1C:203

1:157

2:92

3:37

1:236

2:196

3:104

NS (5-year survival reported)

Zanetta et al

1997

56

43

Unilateral oophorectomy and uterine preservation and surgical staging

Hysterectomy, and bilateral salpingo-oophorectomy with surgical staging

292

342

Mucinous: 23

Endometroid: 13

Serous: 18

Clear cell: 0

Others:2

Mucinous: 10

Endometroid: 10

Serous: 16

Clear cell: 5

Others:02

Y:16

N:40

Y:10

N:33

IA: 32

IB: 2

IC: 22

IA: 27

IB: 3

IC: 13

1:35

2:14

3:7

1:21

2:15

3:7

7.831

  1. 1Median value; 2Mean value
  2. FSS, Fertility sparing surgery; RS, Radical surgery; yr, years; Y, yes; N, No; NS, Not specified; NK, Not known