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Table 1 Characteristics of included studies

From: Fertility sparing surgery vs radical surgery for epithelial ovarian cancer: a meta-analysis of overall survival and disease-free survival

AuthorYearSample sizeFSSRSAge group (yr)HistologyAdjuvant chemo/radio therapyStageGradeFollow-up (yr)
  FSSRS  FSSRSFSSRSFSSRSFSSRSFSSRS 
Crafton et al202012623823Unilateral salpingo-oophorectomy and uterine preservationBilateral salpingo-oophorectomy or hysterectomyRange: 15–44Mucinous: 461
Endometroid: 418
Serous: 309
Clear cell: 368
Mucinous: 682
Endometroid: 1308
Serous: 1465
Clear cell: 368
Y:651
N: 611
Y:2569
N: 1254
IA/B: 590
IC: 321
II-IV: 351
IA/B: 1242
IC: 792
II-IV: 1789
1or2:956
3:306
1or2:2339
3:1484
4.61
Jiang et al20175256Ipsilateral adnexectomy and biopsy or wedge excision of contralateral ovaryHysterectomy and bilateral adnexectomy251351Mucinous: 38
Endometroid: 1
Serous: 1
Clear cell: 2
Mucinous: 14
Endometroid: 16
Serous: 8
Clear cell: 18
Y:33
N:19
Y:50
N:6
IA/B: 19
IC1: 24
IC2/3:9
IA/B: 17
IC1: 31
IC2/3:8
1:45
2:4
3:1
1:27
2:8
3:3
6.91
Frusico et al2016242789Cystectomy or unilateral adnexectomy and complete peritoneal stagingHysterectomy, bilateral salpingo-oophorectomy31.3253.12Mucinous: 101
Endometroid: 55
Serous: 62
Clear cell: 17
Others:7
Mucinous: 152
Endometroid: 203
Serous: 237
Clear cell: 134
Others:56
Y:103
N:139
Y:494
N:295
IA: 129
IB: 2
IC1: 57
IC2/3:46
IA: 337
IB: 63
IC1: 136
IC2/3:223
1:145
2:69
3:27
1:225
2:225
3:320
11.91
Lee et al20153555Unilateral salpingo-oophorectomy with surgical exploration. Surgical staging was optionalPatients other than those undergoing FS surgery28.6250.32Mucinous:35Mucinous:55Y:14
N:21
Y:26
N:29
IA: 21
IB: 0
IC: 13
II: 1
IA: 34
IB: 1
IC: 17
II: 3
1:27
2:5
3:1
NK:2
1:34
2:15
3:2
NK:4
8.61
Ditto et al201570237Preservation of the uterus, of at least one tube and the contralateral ovaryRadical comprehensive staging301511Mucinous: 36
Endometroid: 8
Serous: 18
Others: 8
Mucinous: 2
Endometroid: 71
Serous: 83
Others: 48
Y:26
N:44
Y:169
N:68
IA: 46
IB: 2
IC: 15
II-III: 6
IA: 95
IB: 21
IC: 45
II-III: 76
1:36
2:24
3:9
1:64
2:80
3:85
FSS:6.41
RS:6.81
Kajiyama et al201174498Conservation of the uterus and contralateral ovary and fallopian tube with at least a full peritoneal stagingHysterectomy, and bilateral salpingo-oophorectomy with peritoneal staging≤40< 40 and > 40 age groupsMucinous: 43
Endometroid: 14
Serous: 4
Clear cell: 13
Others:0
Mucinous: 107
Endometroid: 114
Serous: 60
Clear cell: 199
Others: 18
Y:54
N:20
Y:392
N:106
IA: 36
IB: 1
IC1: 21
IC2/3:16
IA: 155
IB: 6
IC1: 145
IC2/3:192
1or2:57
3:4
1or2:266
3:33
FSS:5.21
RS:5.51
Wright et al2009432754Unilateral oophorectomyBilateral oophorectomy< 25:666
25–35: 181
36–50:185
< 25:64
25–35: 68
36–50:682
Mucinous: 211
Endometroid: 90
Serous: 98
Clear cell: 33
Mucinous: 188
Endometroid: 285
Serous: 160
Clear cell: 121
Y: 426
N:3
NK:3
Y: 720
N:22
NK:12
1A:370
1C:62
1A:551
1C:203
1:157
2:92
3:37
1:236
2:196
3:104
NS (5-year survival reported)
Zanetta et al19975643Unilateral oophorectomy and uterine preservation and surgical stagingHysterectomy, and bilateral salpingo-oophorectomy with surgical staging292342Mucinous: 23
Endometroid: 13
Serous: 18
Clear cell: 0
Others:2
Mucinous: 10
Endometroid: 10
Serous: 16
Clear cell: 5
Others:02
Y:16
N:40
Y:10
N:33
IA: 32
IB: 2
IC: 22
IA: 27
IB: 3
IC: 13
1:35
2:14
3:7
1:21
2:15
3:7
7.831
  1. 1Median value; 2Mean value
  2. FSS, Fertility sparing surgery; RS, Radical surgery; yr, years; Y, yes; N, No; NS, Not specified; NK, Not known