Fig. 7
Effects of inhibiting Nodal/Activin signalling on cisplatin-sensitivity in a NTera2 xenograft model. NTera2 cells (2 × 106; single injection) were xenografted into the flanks of nude mice and allowed to grow to an average size of 150 mm3. Animals were allocated into three groups (n = 10 for each group) and treated (day 0 on graph) with vehicle (10 mg/kg DMSO i.p. three times weekly), cisplatin (6 mg/kg i.p. once during the experiment) or cisplatin + SB431542 (6 mg/kg cisplatin i.p. once during the experiment and 10 mg/kg SB431542 i.p. three times weekly). Body weight and tumour size (mm3) were evaluated three times weekly during the experimental period of 11 days. Values represent mean ± SEM. Significant difference compared to vehicle control-treated mice, * P < 0.05, ** P < 0.01 and *** P < 0.001. Abbreviations: i.p., intraperitoneal injection