Fig. 5

Effects of pharmaceutical inhibition of Nodal/Activin or Nodal signalling on cisplatin-sensitivity in NTera2 cells. NTera2 cells were treated for 48 h with SB431542 (5 μM and 20 μM) or Lefty (100 ng/ml) followed by additional 48 h of cisplatin treatment (1 μM and 5 μM) and assessment of cell proliferation. a) Experiments were conducted in three independent experiments with eight replicates per treatment (shown as mean for each experiment). Cell proliferation is set to 1 in NTera2 cells not treated with cisplatin. b) Values represent mean ± SEM from the three independent experiments (n = 3). Significant difference compared to proliferation of vehicle-treated control NTera2 cells receiving corresponding cisplatin treatment, * P < 0.05