Fig. 5From: Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potentialCIN70 score highlights distinct M1 subtypes. Derivation of CIN70 score in individual samples in the PNBX cohort (n = 99) identifies bimodal distribution of M1 cases. a Heat map of PNBX samples organized by CIN70 score (low to high). Clinicopathological information is given in the header according to the legend (disease stage, Gleason sum). PC-CIN genes and specific genes from the CIN70 signature organized into functional groups are shown in accordance with the legend (chromosome replication, condensation, cyclins/cell cycle, cytokinesis, DDR, kinetochores, spindle-related, spindle-related/centrosomes, and spindle-related/cyclins). b Volcano plot highlights distribution of PC-CIN genes among DEGS identified by comparison of M)-NM and M1-poly cases from the PNBX cohort. c Boxplot demonstrates range of significantly higher PC-CIN scores found in M1-poly versus M1-NM PNBX cases. d Box plots demonstrate significantly higher frequency of CNAs found in select M1-poly versus M0-NM cases from the PNBX cohortBack to article page