Fig. 5
From: Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential
CIN70 score highlights distinct M1 subtypes. Derivation of CIN70 score in individual samples in the PNBX cohort (n = 99) identifies bimodal distribution of M1 cases. a Heat map of PNBX samples organized by CIN70 score (low to high). Clinicopathological information is given in the header according to the legend (disease stage, Gleason sum). PC-CIN genes and specific genes from the CIN70 signature organized into functional groups are shown in accordance with the legend (chromosome replication, condensation, cyclins/cell cycle, cytokinesis, DDR, kinetochores, spindle-related, spindle-related/centrosomes, and spindle-related/cyclins). b Volcano plot highlights distribution of PC-CIN genes among DEGS identified by comparison of M)-NM and M1-poly cases from the PNBX cohort. c Boxplot demonstrates range of significantly higher PC-CIN scores found in M1-poly versus M1-NM PNBX cases. d Box plots demonstrate significantly higher frequency of CNAs found in select M1-poly versus M0-NM cases from the PNBX cohort
