Fig. 3
From: Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential
Transcriptome analysis of diagnostic PNBX primary tumors from mCSPC (M1) cases correlate strongly with mCRPC. a PNBX cohort consisting of 99 cases of de novo metastatic (M1) CSPC (n = 63), localized (M0) cases that progressed with metastases (M0-M, n = 13), or high-grade M0 cases without metastatic progression (M0-NM, n = 23). Cases were sub-stratified based upon oligometastatic (M1-oligo) or polymetastatic (M1-poly) tumor burden at diagnosis or following recurrence (M0-oligo or M0-poly). b Correlation matrix of 1234 DEGs determined by comparison of M1 (oligo and poly) versus M0-NM cases from the PNBX cohort. c A Venn diagram depicts the overlap of three sets of DEGs (21 + 36 + 100 DEGs shaded in light blue) for a combined total of 157 shared genes that were revealed from comparison of M1 versus M0-NM PNBX cases with CRPC metastases versus primary tumors from Taylor and Grasso cohorts. d Bar chart showing cellular processes (rows) enriched by 157 common DEGs. Functional enrichment analysis of genes in three clusters was independently performed using DAVID software. e Multi-dimensional scaling of cases from the PNBX, Taylor