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Fig. 2 | BMC Cancer

Fig. 2

From: Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential

Fig. 2

CIN70 scores in primary untreated PCs are most strongly correlated with broad CNAs. a A heat map generated from 473 primary, untreated, clinically localized prostate tumors in TCGA ordered by CIN70 score (high to low) demonstrates the frequency of broad CNAs and focal CNAs (gains in red, losses in blue), mutations, and specific fusions (TMPRSS-ERG, SLC45A3-ERG, and TMPRSS-ETV4). In addition, MANTIS scores reflecting the level of microsatellite instability (MSI) and clinical information, including Gleason sum (see legend to indicated sum of 6,7,8,9,or10) and BCR were included. b A correlation matrix demonstrating links between CIN70 scores and specific genomic aberrations. c Plots of PC samples from TCGA based upon CIN70 score demonstrate positive correlation with broad CNA score and negative correlation with MSI score. d Frequency of somatic CNAs (gains in red, losses in blue) in PC cases from TCGA. Height of peaks indicates the frequency of CNAs at each chromosome

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