Fig. 1
From: Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential
CIN70 score is significantly higher in mCRPC compared to primary tumors. Five transcriptome data from independent PC cohorts that included primary tumors and mCRPC were analyzed for CIN70 activation score. a Box plots comparing primary tumors and metastatic tumors demonstrated overall differences in gene expression scores (rank-sum p < 0.00001 for all). b Volcano plots reflecting differential expression in primary tumors versus metastases were annotated with CIN70 genes (purple) to highlight differential expression in CRPC metastases versus primaries