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Fig. 1 | BMC Cancer

Fig. 1

From: Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

Fig. 1

Schematic of determination and interpretation of patient-specific tumor kinetic parameters. Left: After tumors are segmented on T1Gd and T2/FLAIR images, the volumes of the imaging abnormalities are used to calculate the spherically-equivalent tumor radii. By assuming the volume seen on T1Gd corresponds to a high cell density and that on T2/FLAIR to a lower cell density, the relative sizes of the abnormalities on these two imaging modalities gives an estimated profile or slope of the tumor cell density. The ratio of our biomathematical model parameters D/ϱ is a way to quantify this profile. Right: A tumor that has relatively more diffuse invasion compared to tumor cell proliferation (high D/ ϱ) is expected to have a more diffuse distribution of cell density. Conversely, a tumor with relatively more cell proliferation than diffuse invasion (low D/ϱ) is expected to have a more nodular distribution of cell density (red = high tumor cell density, blue = low tumor cell density). Adapted from Baldock et al. 2014 [17] with permission from Oxford University Press (right) and Corwin et al. 2013 [19] (left)

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