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Fig. 3 | BMC Cancer

Fig. 3

From: Drug resistance occurred in a newly characterized preclinical model of lung cancer brain metastasis

Fig. 3

Traditional lung cancer chemotherapy fails to extend survival and limit CNS tumor burden progression. a On day 21 after intracardiac injection of PC-9-Br cells, mice were treated with vehicle (saline, n = 10), combined cisplatin+etoposide (n = 10), or combined cisplatin+pemetrexed (n = 9). Median survival time was 42 days for vehicle, 51.5 days for cisplatin+etoposide, and 45 days for cisplatin+pemetrexed. Cisplatin+etoposide significantly improved median survival compared to vehicle (p < 0.05), though cisplatin+pemetrexed did not (p > 0.05). All data was analyzed using log-rank statistics. b Mean BLI signal plotted versus time in mice exhibiting intracranial metastases

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