Fig. 2
From: Drug resistance occurred in a newly characterized preclinical model of lung cancer brain metastasis
a Luciferin bioluminescence shows the large PC-9-Br tumor burden. b Fluorescence imaging contrasts the Oregon Green-perfused vasculature and the distribution of Tomato Red-expressing tumors. Four numbered slices correspond to the coronal sections (c-f). c Visualization of brain metastases based on cresyl violet staining. d Tomato Red tumors accurately represent tumor burden confirmed by cresyl violet staining. e Oregon Green highlights normal and disrupted vasculature in tumor brain. f An overlay of Oregon Green and Tomato Red depicts tumor environment and vascular integrity. Scale bars = 1 mm