| Clinical variables | Total cohort | Small duct type |
|---|
| IDH1/2 mutant type | IDH1/2 wild type | P-valve | IDH1/2 mutant type | IDH1/2 wild type | P-valve |
|---|
| TBIL (umol/L) | | 0.122 | | | 0.039 |
| < 21 | 20 (95.2%) | 85 (78.7%) | | 20 (100.0%) | 65 (79.3%) | |
| ≥ 21 | 1 (4.8%) | 23 (21.3%) | | 0 (0.0%) | 17 (20.7%) | |
| INR | | 0.025 | | | 0.054 |
| <1.0 | 17 (81.0%) | 59 (54.6%) | | 16 (80.0%) | 47 (56.6%) | |
| ≥ 1.0 | 4 (19.0%) | 49 (45.4%) | | 4 (20%) | 36 (43.4%) | |
| CEA (ug/L) | | 0.162 | | | 0.067 |
| < 5 | 19 (90.5%) | 82 (75.9%) | | 19 (100.0%) | 68 (81.9%) | |
| ≥ 5 | 2 (9.5%) | 26 (24.1%) | | 0 (0.0%) | 15 (18.1%) | |
| Fe (ug/L) | | 0.000 | | | 0.000 |
| < 200 | 17 (85.0%) | 42 (41.2%) | | 17 (89.5%) | 34 (44.2%) | |
| ≥ 200 | 3 (15.0%) | 60 (58.8%) | | 2 (10.5%) | 43 (55.8%) | |
| Histological differentiation | | 0.028 | | | 0.024 |
| Low | 5 (23.8%) | 53 (50.0%) | | 5 (25.0%) | 44 (53.0%) | |
| Moderately to high | 16 (76.2%) | 53 (50.0%) | | 15 (75.0%) | 39 (47.0%) | |
| Histological subtype | | 0.074 | | | |
| Large duct | 1 (4.8%) | 26 (23.9%) | | | | |
| Small duct | 20 (95.2%) | 83 (76.1%) | | | | |
