Table 3 Comparisons of clinicopathological characteristics between IDH1/2 mutant and wild type of ICCs
Clinical variables | Total cohort | Small duct type | ||||
|---|---|---|---|---|---|---|
IDH1/2 mutant type | IDH1/2 wild type | P-valve | IDH1/2 mutant type | IDH1/2 wild type | P-valve | |
TBIL (umol/L) | Â | 0.122 | Â | Â | 0.039 | |
  < 21 | 20 (95.2%) | 85 (78.7%) |  | 20 (100.0%) | 65 (79.3%) |  |
  ≥ 21 | 1 (4.8%) | 23 (21.3%) |  | 0 (0.0%) | 17 (20.7%) |  |
INR | Â | 0.025 | Â | Â | 0.054 | |
 <1.0 | 17 (81.0%) | 59 (54.6%) |  | 16 (80.0%) | 47 (56.6%) |  |
  ≥ 1.0 | 4 (19.0%) | 49 (45.4%) |  | 4 (20%) | 36 (43.4%) |  |
CEA (ug/L) | Â | 0.162 | Â | Â | 0.067 | |
  < 5 | 19 (90.5%) | 82 (75.9%) |  | 19 (100.0%) | 68 (81.9%) |  |
  ≥ 5 | 2 (9.5%) | 26 (24.1%) |  | 0 (0.0%) | 15 (18.1%) |  |
Fe (ug/L) | Â | 0.000 | Â | Â | 0.000 | |
  < 200 | 17 (85.0%) | 42 (41.2%) |  | 17 (89.5%) | 34 (44.2%) |  |
  ≥ 200 | 3 (15.0%) | 60 (58.8%) |  | 2 (10.5%) | 43 (55.8%) |  |
Histological differentiation | Â | 0.028 | Â | Â | 0.024 | |
 Low | 5 (23.8%) | 53 (50.0%) |  | 5 (25.0%) | 44 (53.0%) |  |
 Moderately to high | 16 (76.2%) | 53 (50.0%) |  | 15 (75.0%) | 39 (47.0%) |  |
Histological subtype | Â | 0.074 | Â | Â | Â | |
 Large duct | 1 (4.8%) | 26 (23.9%) |  |  |  |  |
 Small duct | 20 (95.2%) | 83 (76.1%) |  |  |  |  |