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Table 3 Comparisons of clinicopathological characteristics between IDH1/2 mutant and wild type of ICCs

From: Distinct clinical and prognostic implication of IDH1/2 mutation and other most frequent mutations in large duct and small duct subtypes of intrahepatic cholangiocarcinoma

Clinical variablesTotal cohortSmall duct type
IDH1/2 mutant typeIDH1/2 wild typeP-valveIDH1/2 mutant typeIDH1/2 wild typeP-valve
TBIL (umol/L) 0.122  0.039
  < 2120 (95.2%)85 (78.7%) 20 (100.0%)65 (79.3%) 
  ≥ 211 (4.8%)23 (21.3%) 0 (0.0%)17 (20.7%) 
INR 0.025  0.054
 <1.017 (81.0%)59 (54.6%) 16 (80.0%)47 (56.6%) 
  ≥ 1.04 (19.0%)49 (45.4%) 4 (20%)36 (43.4%) 
CEA (ug/L) 0.162  0.067
  < 519 (90.5%)82 (75.9%) 19 (100.0%)68 (81.9%) 
  ≥ 52 (9.5%)26 (24.1%) 0 (0.0%)15 (18.1%) 
Fe (ug/L) 0.000  0.000
  < 20017 (85.0%)42 (41.2%) 17 (89.5%)34 (44.2%) 
  ≥ 2003 (15.0%)60 (58.8%) 2 (10.5%)43 (55.8%) 
Histological differentiation 0.028  0.024
 Low5 (23.8%)53 (50.0%) 5 (25.0%)44 (53.0%) 
 Moderately to high16 (76.2%)53 (50.0%) 15 (75.0%)39 (47.0%) 
Histological subtype 0.074   
 Large duct1 (4.8%)26 (23.9%)    
 Small duct20 (95.2%)83 (76.1%)