Fig. 3

The representative HE and IHC images of BAP1 (a-d), ARID1A (e-h) and PBRM1 (i-l) expression in cases with ICC. The nuclear staining was detected in cases with the normal expression of BAP1 (b), ARID1A (f) and PBRM1 (j). Similarly, the loss of BAP1 (d), ARID1A (h) and PBRM1 (l) expression were interpreted as inactive mutations of these genes. These corresponding images of HE (a, c, e, g, i, k) were presented as control of each IHC staining (b, d, f, h, j, l), respectively. Scale bar represents 200 um