Skip to main content

Table 2 Univariate and multivariate analysis of patient and treatment factors for survival

From: Retrospective analysis of salvage surgery for local progression of brain metastasis previously treated with stereotactic irradiation: diagnostic contribution, functional outcome, and prognostic factors

Tested VariableNumber (%)UnivariateMultivariate
median OS (M)P valueTested VariableHR95%CIP value
Age at surgery (median; 63.5)
  < 63-years21 (43.8)29.20.4    
  ≥ 63-years27 (56.2)16.8     
Median time from STI to surgery (12mo)
  ≥ 12 months22 (45.8)32.90.13    
  < 12 months26 (54.2)13.1     
Pathological diagnosis
 Radiation necrosis alone6 (12.5)22.80.76    
 Tumor recurrence + Necrosis42 (87.5)20.2     
Gender
 Female16 (33.3)290.11    
 Male32 (66.7)16.8     
Location   Location   
 Supratentrial42 (87.5)25.50.016Supra- vs Infratentrial0.50.18–1.520.2
 Infratentrial6 (12.5)9.1     
Primary cancer   Primary cancer   
 Breast9 (18.8)430.003Breast vs Lung0.20.036–0.550.002
 Lung31 (64.6)16.8 Breast vs Others0.10.013–0.347E-04
 Others8 (16.6)9.4 Lung vs Others0.50.2–1.20.12
Neurological deficit
 No15 (31.3)21.90.56    
 Yes33 (68.7)16.8     
RPA   RPA   
 Class 16 (12.5)NR0.023Class 1 vs 30.10.02–0.510.002
 Class 218 (37.5)21.9 Class 2 vs 30.40.16–0.950.042
 Class 324 (50)11.2 Class 1 vs 20.30.05–0-1.350.13
Surgical technique
 Minimum resection23 (48)25.50.7    
 Resection with free margine25 (52)17.9     
Extent of resection
 Subtotal removal6 (12.5)28.20.98    
 Gross total removal42 (87.5)20.2     
Radiotherapy after salvage surgery
 Yes15 (31.3)20.20.38    
 No33 (68.7)16.8     
  1. *NR not reached